DESIGN AND CHARACTERIZATION OF DICLOFENAC DIETHYLAMINE TRANSDERMAL PATCH USING SILICONE AND ACRYLIC ADHESIVES COMBINATION

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PANCHAXARI DANDIGI M.; PAMPANA SOWJANYA; PAL TAPAS; DEVABHAKTUNI BHAVANA; ARAVAPALLI ANIL KUMAR

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Journal Paper

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Journal: DARU Journal of Pharmaceutical Sciences Year:2013 | Volume:21 | Issue:1 Page(s): 0-0

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Title

DESIGN AND CHARACTERIZATION OF DICLOFENAC DIETHYLAMINE TRANSDERMAL PATCH USING SILICONE AND ACRYLIC ADHESIVES COMBINATION

Author(s)

Keywords

TRANSDERMAL DRUG DELIVERY SYSTEM

SILICONE ADHESIVE

ACRYLIC ADHESIVE

PERMEATION STUDY

DISSOLUTION

SKIN IRRITANCY AND ANTI-INFLAMMATORY

Abstract

Background and purpose of the study: The objective of the study was to develop and characterize Diclofenac Diethylamine (DDEA) transdermal patch using Silicone and ACRYLIC ADHESIVEs combination.Methods: Modified solvent evaporation method was employed for casting of film over Fluoropolymer coated polyester release liner. Initial studies included solubilization of drug in the polymers using solubilizers. The formulations with combination of adhesives were attempted to combine the desirable features of both the adhesives. The effect of the permeation enhancers on the drug permeation were studied using pig ear skin. All the optimized patches were subjected to adhesion, DISSOLUTION and stability studies. A 7-day skin irritancy test on albino rabbits and an in vivo anti-inflammatory study on wistar rats by carrageenan induced paw edema method were also performed.Results: The results indicated the high percent drug permeation (% CDP-23.582) and low solubility nature (1%) of SILICONE ADHESIVE and high solubility (20%) and low% CDP (10.72%) of ACRYLIC ADHESIVE. The combination of adhesives showed desirable characteristics for DDEA permeation with adequate % CDP and sufficient solubility.Release profiles were found to be dependent on proportion of polymer and type of permeation enhancer. The anti-inflammatory study revealed the sustaining effect and high percentage inhibition of edema of C4/OLA (99.68%). The acute skin irritancy studies advocated the non-irritant nature of the adhesives used.Conclusion: It was concluded that an ideal of combination of adhesives would serve as the best choice, for fabrication of DDEA patches, for sustained effect of DDEA with better enhancement in permeation characteristics and robustness.

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APA: Copy

PANCHAXARI, DANDIGI M., PAMPANA, SOWJANYA, PAL, TAPAS, ARAVAPALLI, ANIL KUMAR, & DEVABHAKTUNI, BHAVANA. (2013). DESIGN AND CHARACTERIZATION OF DICLOFENAC DIETHYLAMINE TRANSDERMAL PATCH USING SILICONE AND ACRYLIC ADHESIVES COMBINATION. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 21(1), 0-0. SID. https://sid.ir/paper/275656/en

Vancouver: Copy

PANCHAXARI DANDIGI M., PAMPANA SOWJANYA, PAL TAPAS, ARAVAPALLI ANIL KUMAR, DEVABHAKTUNI BHAVANA. DESIGN AND CHARACTERIZATION OF DICLOFENAC DIETHYLAMINE TRANSDERMAL PATCH USING SILICONE AND ACRYLIC ADHESIVES COMBINATION. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2013;21(1):0-0. Available from: https://sid.ir/paper/275656/en

IEEE: Copy

DANDIGI M. PANCHAXARI, SOWJANYA PAMPANA, TAPAS PAL, ANIL KUMAR ARAVAPALLI, and BHAVANA DEVABHAKTUNI, “DESIGN AND CHARACTERIZATION OF DICLOFENAC DIETHYLAMINE TRANSDERMAL PATCH USING SILICONE AND ACRYLIC ADHESIVES COMBINATION,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 21, no. 1, pp. 0–0, 2013, [Online]. Available: https://sid.ir/paper/275656/en

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