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Information Journal Paper

Title

A CYTOTOXIC HYDROPEROXY STEROL FROM THE BROWN ALGA, NIZAMUDDINIA ZANARDINII

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Abstract

 Background: The marine environment is a unique source of bioactive natural products, of which NIZAMUDDINIA ZANARDINII is an important BROWN ALGAE distributed in Oman Sea. Literature revealed that there is no report on phytochemistry and pharmacology of this valuable algae.Methods: Bioguided fractionation of the methanolic extract of NIZAMUDDINIA ZANARDINII, collected from Oman Sea, led to the isolation of a hydroperoxy STEROL. Its structure was determined by analysis of the spectroscopic data as 24-hydroperoxy-24-vinyl cholesterol (HVC). In vitro cytotoxic activity of this compound was evaluated against HT29, MCF7, A549, HepG2 and MDBK cell lines.Results: Although 24 (R) -hydroproxy-24-vinylcholesterol has been previously reported from Sargassum and Padina species, it is the first report on the presence of this compound from N. zanardinii. This compound exhibited cytotoxicity in all cell lines (IC50, 3.62, 9.09, 17.96, 32.31 and 37.31 mg/mL respectively). HVC was also evaluated for apoptotic activity and demonstrated positive results in terminal deoxynucleotidyl transferase dUTP Nick End labeling (TUNEL) assay suggesting it a candidate for further apoptotic studies.Conclusions: NIZAMUDDINIA ZANARDINII, a remarkable BROWN ALGAE of Oman Sea, is a good source of hydroproxy STEROLs with promising cytotoxic on various cell lines particularly human colon adenocarcinoma.

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    APA: Copy

    HAMZELOO MOGHADAM, MARYAM, FIROUZI, JAMILEH, SAEIDNIA, SOODABEH, HAJIMEHDIPOOR, HOMA, JAMILI, SHAHLA, RUSTAIYAN, ABDOLHOSSEIN, & GOHARI, AHMAD R.. (2013). A CYTOTOXIC HYDROPEROXY STEROL FROM THE BROWN ALGA, NIZAMUDDINIA ZANARDINII. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 21(3), 0-0. SID. https://sid.ir/paper/275670/en

    Vancouver: Copy

    HAMZELOO MOGHADAM MARYAM, FIROUZI JAMILEH, SAEIDNIA SOODABEH, HAJIMEHDIPOOR HOMA, JAMILI SHAHLA, RUSTAIYAN ABDOLHOSSEIN, GOHARI AHMAD R.. A CYTOTOXIC HYDROPEROXY STEROL FROM THE BROWN ALGA, NIZAMUDDINIA ZANARDINII. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2013;21(3):0-0. Available from: https://sid.ir/paper/275670/en

    IEEE: Copy

    MARYAM HAMZELOO MOGHADAM, JAMILEH FIROUZI, SOODABEH SAEIDNIA, HOMA HAJIMEHDIPOOR, SHAHLA JAMILI, ABDOLHOSSEIN RUSTAIYAN, and AHMAD R. GOHARI, “A CYTOTOXIC HYDROPEROXY STEROL FROM THE BROWN ALGA, NIZAMUDDINIA ZANARDINII,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 21, no. 3, pp. 0–0, 2013, [Online]. Available: https://sid.ir/paper/275670/en

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