ANTIOXIDANT CAPACITY OF CALENDULA OFFICINALIS FLOWERS EXTRACT AND PREVENTION OF RADIATION INDUCED OROPHARYNGEAL MUCOSITIS IN PATIENTS WITH HEAD AND NECK CANCERS: A RANDOMIZED CONTROLLED CLINICAL STUDY

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BABAEE NEDA; MOSLEMI DARIUSH; KHALILPOUR MOHAMMAD; VEJDANI FATEMEH; MOGHADAMNIA YASAMAN; BIJANI ALI; BARADARAN MAHMOUD; KAZEMI MOHAMMAD TAGHI; KHALILPOUR ASIEH; POURAMIR MAHDI; MOGHADAMNIA ALI AKBAR

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Journal: DARU Journal of Pharmaceutical Sciences Year:2013 | Volume:21 | Issue:3 Page(s): 0-0

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Title

ANTIOXIDANT CAPACITY OF CALENDULA OFFICINALIS FLOWERS EXTRACT AND PREVENTION OF RADIATION INDUCED OROPHARYNGEAL MUCOSITIS IN PATIENTS WITH HEAD AND NECK CANCERS: A RANDOMIZED CONTROLLED CLINICAL STUDY

Author(s)

Keywords

RADIOTHERAPY-INDUCED ORAL MUCOSITIS

OMAS (ORAL MUCOSITIS ASSESSMENT SCALE)

CALENDULA OFFICINALIS

ANTIOXIDANT CAPACITY

GEL FORMULATION

Abstract

This study was designed to determine the effect of CALENDULA OFFICINALIS flowers extract mouthwash as oral gel on radiation-induced oropharyngeal mucositis (OM) in patients with head-and-neck cancer. Forty patients with neck and head cancers under radiotherapy or concurrent chemoradiotherapy protocols were randomly assigned to receive either 2% calendula extract mouthwash or placebo (20 patients in each group). Patients were treated with telecobalt radiotherapy at conventional fractionation (200 cGy/fraction, five fractions weekly, 30-35 fractions within 4-7 weeks). The oropharyngeal mucositis was evaluated by two clinical investigators (a radiation oncologist and a dentist), using the oral mucositis assessment scale (OMAS). Trying to find out the possible mechanism of action of the treatment, total antioxidant, polyphenol and flavonoid contents, and quercetin concentration of the mouth wash were measured. Calendula mouthwash significantly decreased the intensity of OM compared to placebo at week 2 (score: 5.5 vs.6.8, p=0.019), week 3 (score: 8.25 vs.10.95, p<0.0001) and week 6 (score: 11.4 vs.13.35, p=0.031). Total antioxidant, polyphenol and flavonoid contents and quercetin concentration of the 2% extract were 2353.4±56.5 mM, 313.40±6.52 mg/g, 76.66±23.24 mg/g, and 19.41±4.34 mg/l, respectively. Calendula extract gel could be effective on decreasing the intensity of radiotherapy-induced OM during the treatment and ANTIOXIDANT CAPACITY may be partly responsible for the effect.

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APA: Copy

BABAEE, NEDA, MOSLEMI, DARIUSH, KHALILPOUR, MOHAMMAD, VEJDANI, FATEMEH, MOGHADAMNIA, YASAMAN, BIJANI, ALI, BARADARAN, MAHMOUD, KAZEMI, MOHAMMAD TAGHI, KHALILPOUR, ASIEH, POURAMIR, MAHDI, & MOGHADAMNIA, ALI AKBAR. (2013). ANTIOXIDANT CAPACITY OF CALENDULA OFFICINALIS FLOWERS EXTRACT AND PREVENTION OF RADIATION INDUCED OROPHARYNGEAL MUCOSITIS IN PATIENTS WITH HEAD AND NECK CANCERS: A RANDOMIZED CONTROLLED CLINICAL STUDY. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 21(3), 0-0. SID. https://sid.ir/paper/275672/en

Vancouver: Copy

BABAEE NEDA, MOSLEMI DARIUSH, KHALILPOUR MOHAMMAD, VEJDANI FATEMEH, MOGHADAMNIA YASAMAN, BIJANI ALI, BARADARAN MAHMOUD, KAZEMI MOHAMMAD TAGHI, KHALILPOUR ASIEH, POURAMIR MAHDI, MOGHADAMNIA ALI AKBAR. ANTIOXIDANT CAPACITY OF CALENDULA OFFICINALIS FLOWERS EXTRACT AND PREVENTION OF RADIATION INDUCED OROPHARYNGEAL MUCOSITIS IN PATIENTS WITH HEAD AND NECK CANCERS: A RANDOMIZED CONTROLLED CLINICAL STUDY. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2013;21(3):0-0. Available from: https://sid.ir/paper/275672/en

IEEE: Copy

NEDA BABAEE, DARIUSH MOSLEMI, MOHAMMAD KHALILPOUR, FATEMEH VEJDANI, YASAMAN MOGHADAMNIA, ALI BIJANI, MAHMOUD BARADARAN, MOHAMMAD TAGHI KAZEMI, ASIEH KHALILPOUR, MAHDI POURAMIR, and ALI AKBAR MOGHADAMNIA, “ANTIOXIDANT CAPACITY OF CALENDULA OFFICINALIS FLOWERS EXTRACT AND PREVENTION OF RADIATION INDUCED OROPHARYNGEAL MUCOSITIS IN PATIENTS WITH HEAD AND NECK CANCERS: A RANDOMIZED CONTROLLED CLINICAL STUDY,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 21, no. 3, pp. 0–0, 2013, [Online]. Available: https://sid.ir/paper/275672/en

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