THE EFFECT OF ADIPOSE DERIVED STROMAL CELLS ON OXIDATIVE STRESS LEVEL, LUNG EMPHYSEMA AND WHITE BLOOD CELLS OF GUINEA PIGS MODEL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

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GHORBANI AHMAD; FEIZPOUR AZADEH; HASHEMZAHI MILAD; GHOLAMI LILA; HOSSEINI MAHMOUD; SOUKHTANLOO MOHAMMAD; VAFAEE BAGHERI FARZANEH; KHODAEI ESMAEIL; MOHAMMADIAN ROSHAN NEMA; BOSKABADY MOHAMMAD HOSSEIN

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Journal: DARU Journal of Pharmaceutical Sciences Year:2014 | Volume:22 | Issue:2 Page(s): 1-12

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Title

THE EFFECT OF ADIPOSE DERIVED STROMAL CELLS ON OXIDATIVE STRESS LEVEL, LUNG EMPHYSEMA AND WHITE BLOOD CELLS OF GUINEA PIGS MODEL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

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Keywords

COPD

STROMAL CELLS

MALONDIALDEHYDE

THIOL

EMPHYSEMA

WBC

GUINEA PIGS

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a worldwide epidemic disease and a major cause of death and disability. The present study aimed to elucidate pharmacological effects of adipose derived STROMAL CELLS (ASCs) on pathological and biochemical factors in a guinea pig model of COPD. GUINEA PIGS were randomized into 5 groups including: Control, COPD, COPD+intratracheal delivery of PBS as a vehicle (COPD-PBS), COPD+ intratracheal delivery of ASCs (COPD-ITASC) and COPD+intravenous injection of ASCs (COPD-IVASC). COPD was induced by exposing animals to cigarette smoke for 3 months. Cell therapy was performed immediately after the end of animal exposure to cigarette smoke and 14 days after that, white blood cells, oxidative stress indices and pathological changes of the lung were measured.Results: Compared with control group, EMPHYSEMA was clearly observed in the COPD and COPD-PBS groups (p<0.001). Lung histopathologic changes of COPD-ITASC and COPD-IVASC groups showed non-significant improvement compared to COPD-PBS group. The COPD-ITASC group showed a significant increase in total WBC compared to COPD-PBS group but there was not a significant increase in this regard in COPD-IVASC group. The differential WBC showed no significant change in number of different types of leukocytes. The serum level of MALONDIALDEHYDE (MDA) significantly decreased but THIOL groups of broncho-alveolar lavage fluid (BALF) increased in both cell treated groups (p<0.05 for all cases). Weight of animals decreased during smoke exposure and improved after PBS or cell therapy. However, no significant change was observed between the groups receiving PBS and the ones receiving ASCs.Conclusion: Cell therapy with ASCs can help in reducing oxidative damage during smoking which may collectively hold promise in attenuation of the severity of COPD although the lung structural changes couldn’t be ameliorated with these pharmacological therapeutic methods.

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APA: Copy

GHORBANI, AHMAD, FEIZPOUR, AZADEH, HASHEMZAHI, MILAD, GHOLAMI, LILA, HOSSEINI, MAHMOUD, SOUKHTANLOO, MOHAMMAD, VAFAEE BAGHERI, FARZANEH, KHODAEI, ESMAEIL, MOHAMMADIAN ROSHAN, NEMA, & BOSKABADY, MOHAMMAD HOSSEIN. (2014). THE EFFECT OF ADIPOSE DERIVED STROMAL CELLS ON OXIDATIVE STRESS LEVEL, LUNG EMPHYSEMA AND WHITE BLOOD CELLS OF GUINEA PIGS MODEL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 22(2), 1-12. SID. https://sid.ir/paper/275712/en

Vancouver: Copy

GHORBANI AHMAD, FEIZPOUR AZADEH, HASHEMZAHI MILAD, GHOLAMI LILA, HOSSEINI MAHMOUD, SOUKHTANLOO MOHAMMAD, VAFAEE BAGHERI FARZANEH, KHODAEI ESMAEIL, MOHAMMADIAN ROSHAN NEMA, BOSKABADY MOHAMMAD HOSSEIN. THE EFFECT OF ADIPOSE DERIVED STROMAL CELLS ON OXIDATIVE STRESS LEVEL, LUNG EMPHYSEMA AND WHITE BLOOD CELLS OF GUINEA PIGS MODEL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2014;22(2):1-12. Available from: https://sid.ir/paper/275712/en

IEEE: Copy

AHMAD GHORBANI, AZADEH FEIZPOUR, MILAD HASHEMZAHI, LILA GHOLAMI, MAHMOUD HOSSEINI, MOHAMMAD SOUKHTANLOO, FARZANEH VAFAEE BAGHERI, ESMAEIL KHODAEI, NEMA MOHAMMADIAN ROSHAN, and MOHAMMAD HOSSEIN BOSKABADY, “THE EFFECT OF ADIPOSE DERIVED STROMAL CELLS ON OXIDATIVE STRESS LEVEL, LUNG EMPHYSEMA AND WHITE BLOOD CELLS OF GUINEA PIGS MODEL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 22, no. 2, pp. 1–12, 2014, [Online]. Available: https://sid.ir/paper/275712/en

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