A CASE REPORT OF HEARING LOSS POST USE OF HYDROXYCHLOROQUINE IN A HIV-INFECTED PATIENT

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KHALILI HOSSEIN; DASTAN FARZANEH; DEHGHAN MANSHADI SEYED ALI

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Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2014 | Volume:22 | Issue:1 Page(s): 1-4

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Title

A CASE REPORT OF HEARING LOSS POST USE OF HYDROXYCHLOROQUINE IN A HIV-INFECTED PATIENT

Author(s)

KHALILI HOSSEIN | DASTAN FARZANEH | DEHGHAN MANSHADI SEYED ALI | Issue Writer Certificate

Keywords

ACQUIRED IMMUNODEFICIENCY SYNDROME

CASE REPORT

HEARING LOSS

HUMAN IMMUNODEFICIENCY VIRUS

HYDROXYCHLOROQUINE

Abstract

Objective: A case with reversible symmetrical sensorineural HEARING LOSS following HYDROXYCHLOROQUINE therapy is described.Case summary: A 57-year-old, HUMAN IMMUNODEFICIENCY VIRUS (HIV) positive man was referred to the HIV clinic of Imam Khomeini Hospital, Tehran with chief complaint of bilateral slowly progressive HEARING LOSS starting from two months ago. The man had history of rheumatoid arthritis diagnosed from 3 months ago and was administered HYDROXYCHLOROQUINE 200 mg and prednisolone 5 mg twice daily. Audiometry test showed moderate to severe neuronal HEARING LOSS and reduced speech recognition in both ears of the patient. With suspicion of HYDROXYCHLOROQUINE-induced HEARING LOSS, this drug was discontinued. After 2 months of HYDROXYCHLOROQUINE discontinuation, his audiometry findings were improved.Discussion: A few cases of HYDROXYCHLOROQUINE-induced HEARING LOSS have been reported. All of the cases were non-HIV positive individuals. Irreversible HEARING LOSS was developed following long-term therapy with HYDROXYCHLOROQUINE. The present case was a HIV-positive man who developed HEARING LOSS following short course (one month) HYDROXYCHLOROQUINE therapy and his problem was resolved following discontinuation of HYDROXYCHLOROQUINE and continuation of prednisolone.Conclusions: HYDROXYCHLOROQUINE-induced HEARING LOSS may reversibly occur following short term therapy in HIV patients.

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APA: Copy

KHALILI, HOSSEIN, DASTAN, FARZANEH, & DEHGHAN MANSHADI, SEYED ALI. (2014). A CASE REPORT OF HEARING LOSS POST USE OF HYDROXYCHLOROQUINE IN A HIV-INFECTED PATIENT. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 22(1), 1-4. SID. https://sid.ir/paper/275722/en

Vancouver: Copy

KHALILI HOSSEIN, DASTAN FARZANEH, DEHGHAN MANSHADI SEYED ALI. A CASE REPORT OF HEARING LOSS POST USE OF HYDROXYCHLOROQUINE IN A HIV-INFECTED PATIENT. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2014;22(1):1-4. Available from: https://sid.ir/paper/275722/en

IEEE: Copy

HOSSEIN KHALILI, FARZANEH DASTAN, and SEYED ALI DEHGHAN MANSHADI, “A CASE REPORT OF HEARING LOSS POST USE OF HYDROXYCHLOROQUINE IN A HIV-INFECTED PATIENT,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 22, no. 1, pp. 1–4, 2014, [Online]. Available: https://sid.ir/paper/275722/en

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