مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EFFECTS OF BETAMETHASONE AND GENTAMICIN ON RENAL SCARRING INDUCED BY MANNOSE-SENSITIVE E COLI PYELONEPHRITIS IN RAT

Pages

  130-133

Abstract

 Background: PYELONEPHRITIS can lead to renal scar. Objective: To evaluate the effects of BETAMETHASONE in preventing renal scarring in RAT model of pyelonephritis. Methods: Sixty three female Sprague-Dawley RATs were divided into seven groups. Group A was the control. Mannosesensitive E coli was directly inoculated into the left kidney exposed under general anesthesia in groups C–G. Group B received normal saline. Two days after bacterial inoculation, groups C, E and F received GENTAMICIN for 10 days. Betamethasone was injected for three days to animals in groups of D, E (2 days after bacterial inoculation) and F (5 days after bacterial inoculation). Group G received no treatment. Eight weeks after bacterial inoculation, animals were sacrificed and the volume (amount) of RENAL SCAR was determined using the stereological techniques. Results: Changes in the weight and volume of the kidneys were not statistically significant. No scar was detected in group A, but all other groups including group B with intrarenal injections showed scarring. The volume density and absolute volume of the scar in groups C–G were significantly more than group B (p<0.001), whereas they did not differ significantly from each other. Conclusion: BETAMETHASONE and/or gentamicin, when used two days after induction of PYELONEPHRITIS were not effective in preventing renal scar.

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    APA: Copy

    FALAHZADEH, M.H., NOURAFSHAN, A., TANIDEH, N., BADELI, H.R., & BAZARGANI, A.. (2004). EFFECTS OF BETAMETHASONE AND GENTAMICIN ON RENAL SCARRING INDUCED BY MANNOSE-SENSITIVE E COLI PYELONEPHRITIS IN RAT. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 29(3), 130-133. SID. https://sid.ir/paper/275829/en

    Vancouver: Copy

    FALAHZADEH M.H., NOURAFSHAN A., TANIDEH N., BADELI H.R., BAZARGANI A.. EFFECTS OF BETAMETHASONE AND GENTAMICIN ON RENAL SCARRING INDUCED BY MANNOSE-SENSITIVE E COLI PYELONEPHRITIS IN RAT. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2004;29(3):130-133. Available from: https://sid.ir/paper/275829/en

    IEEE: Copy

    M.H. FALAHZADEH, A. NOURAFSHAN, N. TANIDEH, H.R. BADELI, and A. BAZARGANI, “EFFECTS OF BETAMETHASONE AND GENTAMICIN ON RENAL SCARRING INDUCED BY MANNOSE-SENSITIVE E COLI PYELONEPHRITIS IN RAT,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 29, no. 3, pp. 130–133, 2004, [Online]. Available: https://sid.ir/paper/275829/en

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