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Information Journal Paper

Title

IMMUNOLOGIC FACTORS IN ACUTE RHEUMATIC FEVER COMPARED TO RHEUMATIC HEART DISEASE

Pages

  116-119

Abstract

 Background/Objective: To clarify the state of different IMMUNOLOGIC FACTORS in patients with ACUTE RHEUMATIC FEVER (ARF) and RHEUMATIC HEART DISEASE (RHD) compared to healthy individuals.Patients and Methods: Patients with ARF (#21), patients with RHD six months after the onset of ARF (#19), and healthy children from the same age group with normal physical examination and no history of pharyngitis during the previous month as the control group (#20) were studied. All patients were evaluated and followed for the presence and the severity of carditis, heart failure, and valvular involvement with echocardiography. Antistreptolysin-O (ASO) titer, erythrocyte sedimentation rate (ESR), serum complements C3 and C4, immunoglobins IgA, IgM, and IgG, IgM Rheumatoid Factor (RF), IgM and IgG anti-cardiolipin antibody (ACLA), and IgM and IgG anti-M group A streptococcal protein (AMP) were compared.Results: There was a significant difference for IgG and IgM, ACLA between groups (p=0.005 and p=0.0001, respectively). These results were shown to reflect the difference between patients with ARF and the other two groups. There was a significant difference for IgG AMP between ARF. and RHD groups (p=0.05). There was a significant difference for IgM RF between ARF and RHD groups (p=0.05). There was a significant difference for serum IgG between groups (p=0.0005). This was shown to reflect a significant difference between patients with ARF and the two other groups. Serum IgG was significantly lower in patients with, than in patients without, aortic valve involvement (p=0.039). Similarly, Serum IgG was significantly lower in patients with pericardial effusion (p=0.013).Conclusion: There are significant differences for IgG and IgM ACLA and IgG AMP and serum IgG levels and IgM RF between ARF patients and the other two groups. Whether IgG has a "protective effect" in patients with ARF preventing them from developing pericardial effusion, aortic valve involvement, or other complications is a notable question that must be answered.

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    APA: Copy

    SABRI, M.R., ZOHOURI, D., BORZOUEI, M., GHADERI, A., KOHANTEB, J., & ALAVIAN GHAVANINI, A.. (2001). IMMUNOLOGIC FACTORS IN ACUTE RHEUMATIC FEVER COMPARED TO RHEUMATIC HEART DISEASE. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 26(3-4), 116-119. SID. https://sid.ir/paper/276070/en

    Vancouver: Copy

    SABRI M.R., ZOHOURI D., BORZOUEI M., GHADERI A., KOHANTEB J., ALAVIAN GHAVANINI A.. IMMUNOLOGIC FACTORS IN ACUTE RHEUMATIC FEVER COMPARED TO RHEUMATIC HEART DISEASE. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2001;26(3-4):116-119. Available from: https://sid.ir/paper/276070/en

    IEEE: Copy

    M.R. SABRI, D. ZOHOURI, M. BORZOUEI, A. GHADERI, J. KOHANTEB, and A. ALAVIAN GHAVANINI, “IMMUNOLOGIC FACTORS IN ACUTE RHEUMATIC FEVER COMPARED TO RHEUMATIC HEART DISEASE,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 26, no. 3-4, pp. 116–119, 2001, [Online]. Available: https://sid.ir/paper/276070/en

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