EFFICACY OF COMBINATION THERAPY WITH METHOTREXATE AND MISOPROSTOL IN TERMINATION OF PREGNANCY IN THE FIRST TRIMESTER

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VAHID ROUDSARI FATEMEH; AYATI SEDIGHEH; SHAKERI M.T.

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Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2009 | Volume:34 | Issue:2 Page(s): 116-120

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Title

EFFICACY OF COMBINATION THERAPY WITH METHOTREXATE AND MISOPROSTOL IN TERMINATION OF PREGNANCY IN THE FIRST TRIMESTER

Author(s)

VAHID ROUDSARI FATEMEH | AYATI SEDIGHEH | SHAKERI M.T. | Issue Writer Certificate

Keywords

MEDICAL ABORTION

MISOPROSTOL

METHOTREXATE

FIRST TRIMESTER OF PREGNANCY

INDUCED ABORTION

MISSED ABORTION

Abstract

Background: INDUCED ABORTION is the medical or surgical termination of pregnancy before fetal viability. It has maternal or fetal indications. The aim of the present study was to evaluate the efficacy of the combination of METHOTREXATE and MISOPROSTOL for termination of the pregnancy in the first trimester. Methods: This analytic study was performed on 100 women at the FIRST TRIMESTER OF PREGNANCY (<14th week), during 2004- 2006. Each woman received intramuscular METHOTREXATE (50 mg/m2) and intravaginal MISOPROSTOL (800 mg) 72 hours after METHOTREXATE administration. The second dose of MISOPROSTOL was administered if abortion did not occur after 24 hours. Abdominal ultrasonography was performed 7 days after abortion.Results: Of the 100 women, 76 had gestational age>9 weeks and 24 has gestational age<9 weeks. Eighty one women (81%) had successful MEDICAL ABORTION and 19% women required curettage. Fifty nine patients with gestational age>9 weeks and 22 patients with gestational age<9 weeks had complete abortion. Failure rate was higher in MISSED ABORTION. Required dose of MISOPROSTOL and duration of conceptus expulsion were higher in pregnancies with MISSED ABORTION.Conclusion: Combination therapy with METHOTREXATE and MISOPROSTOL represents a safe and effective alternative to invasive methods for termination of the pregnancy in the first trimester.

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APA: Copy

VAHID ROUDSARI, FATEMEH, AYATI, SEDIGHEH, & SHAKERI, M.T.. (2009). EFFICACY OF COMBINATION THERAPY WITH METHOTREXATE AND MISOPROSTOL IN TERMINATION OF PREGNANCY IN THE FIRST TRIMESTER. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 34(2), 116-120. SID. https://sid.ir/paper/276262/en

Vancouver: Copy

VAHID ROUDSARI FATEMEH, AYATI SEDIGHEH, SHAKERI M.T.. EFFICACY OF COMBINATION THERAPY WITH METHOTREXATE AND MISOPROSTOL IN TERMINATION OF PREGNANCY IN THE FIRST TRIMESTER. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2009;34(2):116-120. Available from: https://sid.ir/paper/276262/en

IEEE: Copy

FATEMEH VAHID ROUDSARI, SEDIGHEH AYATI, and M.T. SHAKERI, “EFFICACY OF COMBINATION THERAPY WITH METHOTREXATE AND MISOPROSTOL IN TERMINATION OF PREGNANCY IN THE FIRST TRIMESTER,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 34, no. 2, pp. 116–120, 2009, [Online]. Available: https://sid.ir/paper/276262/en

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