Effects of Two-by-Two Combination Therapy with Valproic Acid, Lithium Chloride, and Celecoxib on the Angiogenesis of the Chicken Chorioallantoic Membrane

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Afzal Ehsan; Alinezhad Sedigheh; KHORSAND MARJAN; Khoshnood Mohammad Javad; TAKHSHID MOHAMMAD ALI

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Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2018 | Volume:43 | Issue:5 Page(s): 506-513

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Title

Effects of Two-by-Two Combination Therapy with Valproic Acid, Lithium Chloride, and Celecoxib on the Angiogenesis of the Chicken Chorioallantoic Membrane

Author(s)

Keywords

Angiogenesis inhibitors

Combined modality therapy

Valproic acid

Celecoxib

Lithium chloride

Abstract

Background: The synergistic effects of Valproic acid (VPA), lithium (Li), and Celecoxib (CX) have been shown in combination therapy against the proliferation and metastasis of numerous cancers. Angiogenesis plays a critical role in the pathogenesis of tumor growth and metastasis. The aim of the present study was to evaluate the antiangiogenic effects of VPA, Lithium chloride (LiCl), and CX, alone or in 2-by-2 combinations, using the chicken chorioallantoic membrane (CAM) assay. Methods: Fertilized chicken eggs were randomly divided into 10 groups: control, VPA (1. 8 and 3. 6 μ mol/CAM), Li (0. 15 and 0. 60 μ mol/CAM), CX (0. 02 and 0. 08 μ mol/CAM), VPA+Li, VPA+CX, and CX+Li (n=10 per group). A window was made on the eggshells and the CAMs were exposed to a filter disk containing VPA, LiCl, and CX, alone or in 2-by-2 combinations. The control CAMs were treated with distilled water (vehicle). Three days after the treatment, the number of vessel branch points was counted in each CAM. The data were analyzed using SPSS, version 15. One-way ANOVA, followed by the Tukey tests, was used to compare the groups. A P<0. 05 was considered a statistically significant difference between the groups. Results: According to the results, all the tested drugs decreased the number of the vessel branch points in a dose-dependent manner compared to the control group (P<0. 001). In addition, combinations of the drugs were more effective in decreasing angiogenesis than the use of each drug alone. Conclusion: These findings suggest that 2-by-2 combinations of VPA, CX, and LiCl can be considered an effective antiangiogenesis therapeutic modality.

Cites

Sodium valproate ameliorates aluminum-induced oxidative stress and apoptosis of PC12 cells

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APA: Copy

Afzal, Ehsan, Alinezhad, Sedigheh, KHORSAND, MARJAN, Khoshnood, Mohammad Javad, & TAKHSHID, MOHAMMAD ALI. (2018). Effects of Two-by-Two Combination Therapy with Valproic Acid, Lithium Chloride, and Celecoxib on the Angiogenesis of the Chicken Chorioallantoic Membrane. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 43(5), 506-513. SID. https://sid.ir/paper/276602/en

Vancouver: Copy

Afzal Ehsan, Alinezhad Sedigheh, KHORSAND MARJAN, Khoshnood Mohammad Javad, TAKHSHID MOHAMMAD ALI. Effects of Two-by-Two Combination Therapy with Valproic Acid, Lithium Chloride, and Celecoxib on the Angiogenesis of the Chicken Chorioallantoic Membrane. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2018;43(5):506-513. Available from: https://sid.ir/paper/276602/en

IEEE: Copy

Ehsan Afzal, Sedigheh Alinezhad, MARJAN KHORSAND, Mohammad Javad Khoshnood, and MOHAMMAD ALI TAKHSHID, “Effects of Two-by-Two Combination Therapy with Valproic Acid, Lithium Chloride, and Celecoxib on the Angiogenesis of the Chicken Chorioallantoic Membrane,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 43, no. 5, pp. 506–513, 2018, [Online]. Available: https://sid.ir/paper/276602/en

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