PARTIAL PURIFICATION OF A POTENT IMMUNOSUPPRESSIVE FACTOR EXCRETED FROM LEISHMANIA MAJOR PROMASTIGOTE AND AMASTIGOTE

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ABOU ALHASANI MOHSEN; DARABI HAYEDEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Iranian Biomedical Journal Year:2004 | Volume:8 | Issue:2 Page(s): 95-99

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Title

PARTIAL PURIFICATION OF A POTENT IMMUNOSUPPRESSIVE FACTOR EXCRETED FROM LEISHMANIA MAJOR PROMASTIGOTE AND AMASTIGOTE

Author(s)

ABOU ALHASANI MOHSEN | DARABI HAYEDEH | Issue Writer Certificate

Keywords

LEISHMANIA MAJOR

AMASTIGOTE

PROMASTIGOTE

IMMUNOSUPPRESSIVE FACTOR

PURIFICATION

Abstract

Recent scientific evidence indicates that distinct patterns of susceptibility in BALB/c mice to LEISHMANIA MAJOR infection are attributable to the differential expansion of distinct CD4+ T-cell subsets and their cytokines production. Production of the Th1 cytokine IFN-g is associated with resistance, whereas production of the Th2 cytokines IL-4 and IL-10 are associated with extreme susceptibility. The major host immune defense mechanism against Leishmania is activation of macrophages by INF-? derived from T cells. The inability of susceptible hosts to mount the immune response necessary to activate macrophage and destroy the parasites may be due to the parasite-specific proteins that are able to suppress the immune system. In the present study, we have semi-purified the excreted antigens of LEISHMANIA MAJOR PROMASTIGOTE and AMASTIGOTE by column chromatography. The isolated fraction showed a potent immunosuppressive activity on normal BALB/c mice lymphocytes stimulated with mitogens. Fifteen microgram of the isolated fraction caused 81% suppression of lymphocyte proliferation. These data may suggest that the parasite by secreting IMMUNOSUPPRESSIVE FACTOR down regulate the immune system and as a result survive in the body.

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APA: Copy

ABOU ALHASANI, MOHSEN, & DARABI, HAYEDEH. (2004). PARTIAL PURIFICATION OF A POTENT IMMUNOSUPPRESSIVE FACTOR EXCRETED FROM LEISHMANIA MAJOR PROMASTIGOTE AND AMASTIGOTE. IRANIAN BIOMEDICAL JOURNAL, 8(2), 95-99. SID. https://sid.ir/paper/277012/en

Vancouver: Copy

ABOU ALHASANI MOHSEN, DARABI HAYEDEH. PARTIAL PURIFICATION OF A POTENT IMMUNOSUPPRESSIVE FACTOR EXCRETED FROM LEISHMANIA MAJOR PROMASTIGOTE AND AMASTIGOTE. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2004;8(2):95-99. Available from: https://sid.ir/paper/277012/en

IEEE: Copy

MOHSEN ABOU ALHASANI, and HAYEDEH DARABI, “PARTIAL PURIFICATION OF A POTENT IMMUNOSUPPRESSIVE FACTOR EXCRETED FROM LEISHMANIA MAJOR PROMASTIGOTE AND AMASTIGOTE,” IRANIAN BIOMEDICAL JOURNAL, vol. 8, no. 2, pp. 95–99, 2004, [Online]. Available: https://sid.ir/paper/277012/en

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