AMBIVALENT EFFECTS OF ATORVASTATIN ON ANGIOGENESIS, EPIDERMAL CELL PROLIFERATION AND TUMORGENESIS IN ANIMAL MODELS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GARJANI ALIREZA; REZAZADEH HASSAN; ANDALIB SINA; ZIAEE MOJTABA; DOUSTAR YOUSEF; SORAYA HAMID; GARJANI MEHRAVEH; KHORRAMI ARASH; ASADPOOR MOSTAFA; MALEKI DIZAJI NASRIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Biomedical Journal Year:2012 | Volume:16 | Issue:2 Page(s): 59-67

Download Full-Text

View:

298

Download:

166

Cites:

Information Journal Paper

Title

AMBIVALENT EFFECTS OF ATORVASTATIN ON ANGIOGENESIS, EPIDERMAL CELL PROLIFERATION AND TUMORGENESIS IN ANIMAL MODELS

Author(s)

Keywords

ATORVASTATIN

ANGIOGENESIS

CELL PROLIFERATION

CANCER

Abstract

Background: A growing body of preclinical data indicates that statins may possess antineoplastic properties; however, some studies have raised the possibility that statins may also have carcinogenic potential.Methods: An air pouch model was used for ANGIOGENESIS. Single or multiple applications of croton oil on the back of Swiss albino mice with or without initiation by dimethylbenz(a)antheracene (DMBA) were used to evaluate the skin tumorgenesis, ultrastructural and histological alterations.Results: ATORVASTATIN (orally, 10 mg/kg/day) produced a significant (P<0.05) reduction in ANGIOGENESIS. Concurrent administration of mevalonate reversed the antiangiogenic effect of ATORVASTATIN. However, local injection of ATORVASTATIN (200 mg) into the pouches induced a significant (P<0.5) increase in ANGIOGENESIS that was not reversed by co-administration of mevalonate. The disturbance of cell polarity, inflammatory response, thickness of epidermal layer, and mitotic index induced by croton oil were inhibited markedly and dose-dependently (P<0.001) by pre-treatment with ATORVASTATIN. In spite of the strong anti-inflammatory and anti-proliferative effects of ATORVASTATIN on epidermal CELL PROLIFERATION, it was identified that the same doses of ATORVASTATIN in DMBA-initiated and croton oil-promoted skin tumorgenesis in mice increased the incidence of tumors and their conversion into malignant carcinoma.Conclusion: The reasons for these discrepancies remain unclear, and could be related to ambivalent effects of ATORVASTATIN on ANGIOGENESIS or to specific differences in the experimental conditions. It is suggested that the pro-angiogenic effect of the drug, which could be responsible for promotion of skin tumors, is independent of the 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibition that can be mediated directly by ATORVASTATIN.

Cites

No record.

References

No record.

Cite

APA: Copy

GARJANI, ALIREZA, REZAZADEH, HASSAN, ANDALIB, SINA, ZIAEE, MOJTABA, DOUSTAR, YOUSEF, SORAYA, HAMID, GARJANI, MEHRAVEH, KHORRAMI, ARASH, ASADPOOR, MOSTAFA, & MALEKI DIZAJI, NASRIN. (2012). AMBIVALENT EFFECTS OF ATORVASTATIN ON ANGIOGENESIS, EPIDERMAL CELL PROLIFERATION AND TUMORGENESIS IN ANIMAL MODELS. IRANIAN BIOMEDICAL JOURNAL, 16(2), 59-67. SID. https://sid.ir/paper/277330/en

Vancouver: Copy

GARJANI ALIREZA, REZAZADEH HASSAN, ANDALIB SINA, ZIAEE MOJTABA, DOUSTAR YOUSEF, SORAYA HAMID, GARJANI MEHRAVEH, KHORRAMI ARASH, ASADPOOR MOSTAFA, MALEKI DIZAJI NASRIN. AMBIVALENT EFFECTS OF ATORVASTATIN ON ANGIOGENESIS, EPIDERMAL CELL PROLIFERATION AND TUMORGENESIS IN ANIMAL MODELS. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2012;16(2):59-67. Available from: https://sid.ir/paper/277330/en

IEEE: Copy

ALIREZA GARJANI, HASSAN REZAZADEH, SINA ANDALIB, MOJTABA ZIAEE, YOUSEF DOUSTAR, HAMID SORAYA, MEHRAVEH GARJANI, ARASH KHORRAMI, MOSTAFA ASADPOOR, and NASRIN MALEKI DIZAJI, “AMBIVALENT EFFECTS OF ATORVASTATIN ON ANGIOGENESIS, EPIDERMAL CELL PROLIFERATION AND TUMORGENESIS IN ANIMAL MODELS,” IRANIAN BIOMEDICAL JOURNAL, vol. 16, no. 2, pp. 59–67, 2012, [Online]. Available: https://sid.ir/paper/277330/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops