EFFECT OF COMBINATION THERAPY USING HYPOTHERMIA AND GRANULOCYTE COLONY-STIMULATING FACTOR IN A RAT TRANSIENT MIDDLE CEREBRAL ARTERY OCCLUSION MODEL

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GHAHARI LAYA; SAFARI MANOUCHEHR; JOGHATAEI MOHAMAD TAGHI; MEHDIZADEH MEHDI; SOLEIMANI MANSOUREH

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Journal: Iranian Biomedical Journal Year:2014 | Volume:18 | Issue:4 Page(s): 239-244

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Title

EFFECT OF COMBINATION THERAPY USING HYPOTHERMIA AND GRANULOCYTE COLONY-STIMULATING FACTOR IN A RAT TRANSIENT MIDDLE CEREBRAL ARTERY OCCLUSION MODEL

Author(s)

Keywords

GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF)

RATS

BRAIN ISCHEMIA

HYPOTHERMIA

Abstract

Background: Stroke is the third leading cause of death. HYPOTHERMIA has been recognized as an effective method in reducing brain injury. In this study, we assessed the effects of granulocyte colony-stimulating factor (G-CSF) as a neuroprotective agent and mild HYPOTHERMIA on mortality, behavioral function, infarct volume, and brain edema in Wistar RATS. Methods: Forty male RATS were used in five groups (eight RATS in each group): control, hypothermy, GCSF, combination hypothermy + CSF, and sham. RATS were anesthetized by injection of chloral hydrate (400 mg/kg) intraperitoneally. Transient cerebral ischemia was induced by 60-min intraluminal occlusion of left middle cerebral artery. HYPOTHERMIA, initiated at the time of reperfusion and G-CSF was started one hour after reperfusion at a dose of 15 mg/kg subcutaneously. The motor behavior was measured using Garcia’s index and animals were assigned for the assessments of infarction, brain swelling, and mortality rate. Results: The mortality was 38.46% (control group) and reduced in other groups. Neurological deficit score of control group (40.31 ± 1.56) was significantly lower than in treatment groups. The total cerebral infarct volume of treatment group was significantly lower than control group (43.96 ± 44.05 mm3). Treatment with hypothermy plus G-CSF (2.69 ± 0.24%) could significantly reduce brain swelling volume than other treatment groups. Conclusion: Our major finding is that mild hypothermic treatment plus G-CSF significantly reduced mortality rate and edema and improved neurological function. The results suggest that the combination of HYPOTHERMIA and G-CSF is more effectively than other treatment groups being used alone.

Cites

THE EFFECT OF CRYOTHERAPY ON INFLAMMATION AND VOLUME OF POST-HYPOXIC LESIONS IN MALE RAT

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APA: Copy

GHAHARI, LAYA, SAFARI, MANOUCHEHR, JOGHATAEI, MOHAMAD TAGHI, MEHDIZADEH, MEHDI, & SOLEIMANI, MANSOUREH. (2014). EFFECT OF COMBINATION THERAPY USING HYPOTHERMIA AND GRANULOCYTE COLONY-STIMULATING FACTOR IN A RAT TRANSIENT MIDDLE CEREBRAL ARTERY OCCLUSION MODEL. IRANIAN BIOMEDICAL JOURNAL, 18(4), 239-244. SID. https://sid.ir/paper/277351/en

Vancouver: Copy

GHAHARI LAYA, SAFARI MANOUCHEHR, JOGHATAEI MOHAMAD TAGHI, MEHDIZADEH MEHDI, SOLEIMANI MANSOUREH. EFFECT OF COMBINATION THERAPY USING HYPOTHERMIA AND GRANULOCYTE COLONY-STIMULATING FACTOR IN A RAT TRANSIENT MIDDLE CEREBRAL ARTERY OCCLUSION MODEL. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2014;18(4):239-244. Available from: https://sid.ir/paper/277351/en

IEEE: Copy

LAYA GHAHARI, MANOUCHEHR SAFARI, MOHAMAD TAGHI JOGHATAEI, MEHDI MEHDIZADEH, and MANSOUREH SOLEIMANI, “EFFECT OF COMBINATION THERAPY USING HYPOTHERMIA AND GRANULOCYTE COLONY-STIMULATING FACTOR IN A RAT TRANSIENT MIDDLE CEREBRAL ARTERY OCCLUSION MODEL,” IRANIAN BIOMEDICAL JOURNAL, vol. 18, no. 4, pp. 239–244, 2014, [Online]. Available: https://sid.ir/paper/277351/en

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