DETERMINATION OF INCIDENCE OF MACROPROLACTINEMIA IN HYPERPROLACTINEMIA BY POLY ETHYLEN GLYCOL AND EVALUATION OF ITS CLINICAL AND RADIOLOGICAL FINDINGS

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TAGHAVI SEYED MORTEZA; GHAFARZADEGAN KAMRAN; MOMENI A.

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Paper Information

Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2006 | Volume:8 | Issue:3 (SN 31) Page(s): 269-274

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Title

DETERMINATION OF INCIDENCE OF MACROPROLACTINEMIA IN HYPERPROLACTINEMIA BY POLY ETHYLEN GLYCOL AND EVALUATION OF ITS CLINICAL AND RADIOLOGICAL FINDINGS

Author(s)

TAGHAVI SEYED MORTEZA | GHAFARZADEGAN KAMRAN | MOMENI A. | Issue Writer Certificate

Keywords

HYPERPROLACTINEMIAQ3

PROLACTINQ3

MACROPROLACTINEMIAQ3

HYPERPROLACTINEMIAQ3

BIG BIG PROLACTINQ3

Abstract

Introduction: PROLACTIN exists in 3 different molecular forms, i.e., monomeric, big and at times big big (macroprolactine) in human serum. Macroprolactine is a complex of PROLACTINe and IgG and may account for a significant proportion of idiopathic HYPERPROLACTINEMIA. Its biological activity is considered low or absent, but it is measured by the common immunoassay method, thus can lead to expensive explorations and ineffective treatments. Conventionally the diagnosis of MACROPROLACTINEMIA has been done by Gel Filtration Chromatography, which cannot be used routinely. Recently Poly Ethylene Glycol has been employed to precipitate macroprolactine, allowing its rapid detection, dependably and inexpensively. The objective of the present work is to assess the incidence of MACROPROLACTINEMIA in patients with HYPERPROLACTINEMIA, by its identification with PEG, and to establish the clinical (galactorrhea and oligomenorrhea) and radiological findings (sella MRI) of such a cohort. Materials and Methods: 50 patients with HYPERPROLACTINEMIA were investigated for macroprolactine. PROLACTINe was measured before and after precipitation of macroprolactine by PEG, with recovery of <= 40% taken as indicating significant macrorprolactinemia. Results: Macroprolactine was found in 14(28%) patients. In true hyperprolactinemic patients (36 patients) galactorrhea occurred in 59.4%, and oligomenorrhea occurred in 65.6% of patients, but in macroprolactinemic patients, galactorrhea occurred in 8.3% and oligomenorrhea occurred in 25% of patients. Also normal pituitary images were found in 41.2% of patients who had true HYPERPROLACTINEMIA and in 85.7% of patients with MACROPROLACTINEMIA.

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APA: Copy

TAGHAVI, SEYED MORTEZA, GHAFARZADEGAN, KAMRAN, & MOMENI, A.. (2006). DETERMINATION OF INCIDENCE OF MACROPROLACTINEMIA IN HYPERPROLACTINEMIA BY POLY ETHYLEN GLYCOL AND EVALUATION OF ITS CLINICAL AND RADIOLOGICAL FINDINGS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 8(3 (SN 31)), 269-274. SID. https://sid.ir/paper/27827/en

Vancouver: Copy

TAGHAVI SEYED MORTEZA, GHAFARZADEGAN KAMRAN, MOMENI A.. DETERMINATION OF INCIDENCE OF MACROPROLACTINEMIA IN HYPERPROLACTINEMIA BY POLY ETHYLEN GLYCOL AND EVALUATION OF ITS CLINICAL AND RADIOLOGICAL FINDINGS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2006;8(3 (SN 31)):269-274. Available from: https://sid.ir/paper/27827/en

IEEE: Copy

SEYED MORTEZA TAGHAVI, KAMRAN GHAFARZADEGAN, and A. MOMENI, “DETERMINATION OF INCIDENCE OF MACROPROLACTINEMIA IN HYPERPROLACTINEMIA BY POLY ETHYLEN GLYCOL AND EVALUATION OF ITS CLINICAL AND RADIOLOGICAL FINDINGS,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 8, no. 3 (SN 31), pp. 269–274, 2006, [Online]. Available: https://sid.ir/paper/27827/en

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