EFFECT OF CHEMICAL MODIFICATION INDUCED BY COPPER OXIDATION ON LIPOPROTEIN (A) BINDING SITE FUNCTION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KADKHODAEI ELYADERANI M.; FAEZIZADEH Z.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2006 | Volume:8 | Issue:3 (SN 31) Page(s): 223-229

Download Full-Text

Persian Verion

View:

1,167

Download:

Cites:

Information Journal Paper

Title

EFFECT OF CHEMICAL MODIFICATION INDUCED BY COPPER OXIDATION ON LIPOPROTEIN (A) BINDING SITE FUNCTION

Author(s)

KADKHODAEI ELYADERANI M. | FAEZIZADEH Z. | Issue Writer Certificate

Keywords

LP(A)Q3

FIBRINOLYSISQ3

OXIDATIONQ3

CHROMATOGRAPHYQ3

Abstract

Introduction: High Lp(a)level in human serum appears to be associated with increased risk for athero- thrombosis. Pathogenecity of Lp(a) as a risk factor may depend on its lysine binding site [LBS] activity, which imparts a unique function to Lp(a), including a potential to inhibit ibrinolysis. Lp(a) is present in human plasma in four heterogeneous subspecies: (Lp(a)Lys-, Lp(a) Lys+1, Lp (a)Lys+2, Lp(a)Lys+3). This subclassification is made according to their ability to bind to lysine sepharose. Data available indicate that serum lipoproteins are sensitive to copper-induced OXIDATION. In this study the effect of copper OXIDATION on lysine binding site properties of Lp (a) was investigated, to find information about molecular mechanism of Lp (a) in promoting thrombosis and atherosclerosis. Materials and Method: Serum lipids were oxidized in the presence of 15, 30, 50, 75 and 100mm of CuCl2. Lipid OXIDATION was measured as conjugated diene formation determined by spectrophotometric method at 245 nm. Four species of Lp(a) in the oxidized serum were isolated using affinity CHROMATOGRAPHY on lysine sepharose. Results: Results showed a concentration dependent increase in all subtypes of Lp(a)Lys+ and a decrease in all subtypes of Lp (a) Lys-. These data suggest that copper ion can induce a chemical modificaton to lipoprotein (a) leading to an increase in LBS activity of Lp(a), and thus, can promote athero- thrombosis.

Cites

No record.

References

No record.

Cite

APA: Copy

KADKHODAEI ELYADERANI, M., & FAEZIZADEH, Z.. (2006). EFFECT OF CHEMICAL MODIFICATION INDUCED BY COPPER OXIDATION ON LIPOPROTEIN (A) BINDING SITE FUNCTION. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 8(3 (SN 31)), 223-229. SID. https://sid.ir/paper/27833/en

Vancouver: Copy

KADKHODAEI ELYADERANI M., FAEZIZADEH Z.. EFFECT OF CHEMICAL MODIFICATION INDUCED BY COPPER OXIDATION ON LIPOPROTEIN (A) BINDING SITE FUNCTION. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2006;8(3 (SN 31)):223-229. Available from: https://sid.ir/paper/27833/en

IEEE: Copy

M. KADKHODAEI ELYADERANI, and Z. FAEZIZADEH, “EFFECT OF CHEMICAL MODIFICATION INDUCED BY COPPER OXIDATION ON LIPOPROTEIN (A) BINDING SITE FUNCTION,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 8, no. 3 (SN 31), pp. 223–229, 2006, [Online]. Available: https://sid.ir/paper/27833/en

Related Journal Papers