Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

296
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

96
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

THE INFLUENCE OF COMBINED GENOTYPES OF THE HLADRB1*1501 AND CD24 SINGLE NUCLEOTIDE POLYMORPHISM ON DISEASE SEVERITY OF IRANIAN MULTIPLE SCLEROSIS PATIENTS

Pages

  418-423

Keywords

HLA-DRB1*1501 

Abstract

 MULTIPLE SCLEROSIS (MS) is an inflammatory demyelinating disease of the central nervous system.It is a clinically heterogeneous disorder especially in terms of disease severity. Current investigations suggest that genes and gene-gene interactions not only influence on susceptibility to MS but also affect the disease severity. In this study, we investigated the contribution of the HLADRB1*1501 allele and single nucleotide polymorphism (SNP) in CD24 gene and also combined genotypes of the HLADRB1*1501 and CD24 SNP to disease severity in Iranian MS patients. We have reported previously that the HLA- DRB1*1501 allele and the CD24v/v genotype associated with disease susceptibility and some other studies proposed that HLADRB1* 1501 allele be associated with MS severity. In this study, the results showed a significant difference in the MULTIPLE SCLEROSIS Severity Score (MSSS) of the nine different genotypes (F=2.838, P=0.007).Subsequent analysis revealed a statistically significant difference in the MSSS between the MS patients who were carriers of HLA-DRB1*1501/1501 and those who were not carriers of HLA-DRB1*1501/1501 genotypes (P=0.04). Moreover, the MS patients carrying combined genotypes of the HLA- DRB1*1501/x- CD24 v/v had statistically severe disease than the patients who did not carry the HLA- DRB1*1501- CD24 v/v (P=0.047). In conclusion, our findings suggest that, HLA-DRB1*1501/1501 and bigenic genotypes of the HLA- DRB1*1501/x- CD24 v/v may influence on disease severity in Iranian MS patients.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    GHLICHNIA, HOSSEIN ALI, KOLLAEE, ABOLGHASEM, GAFFARPOOR, MAJID, MOVAFAGH, ABOLFAZL, GHLICHNIA, BABAK, & ZAMANI, MAHDI. (2014). THE INFLUENCE OF COMBINED GENOTYPES OF THE HLADRB1*1501 AND CD24 SINGLE NUCLEOTIDE POLYMORPHISM ON DISEASE SEVERITY OF IRANIAN MULTIPLE SCLEROSIS PATIENTS. ACTA MEDICA IRANICA, 52(6), 418-423. SID. https://sid.ir/paper/278636/en

    Vancouver: Copy

    GHLICHNIA HOSSEIN ALI, KOLLAEE ABOLGHASEM, GAFFARPOOR MAJID, MOVAFAGH ABOLFAZL, GHLICHNIA BABAK, ZAMANI MAHDI. THE INFLUENCE OF COMBINED GENOTYPES OF THE HLADRB1*1501 AND CD24 SINGLE NUCLEOTIDE POLYMORPHISM ON DISEASE SEVERITY OF IRANIAN MULTIPLE SCLEROSIS PATIENTS. ACTA MEDICA IRANICA[Internet]. 2014;52(6):418-423. Available from: https://sid.ir/paper/278636/en

    IEEE: Copy

    HOSSEIN ALI GHLICHNIA, ABOLGHASEM KOLLAEE, MAJID GAFFARPOOR, ABOLFAZL MOVAFAGH, BABAK GHLICHNIA, and MAHDI ZAMANI, “THE INFLUENCE OF COMBINED GENOTYPES OF THE HLADRB1*1501 AND CD24 SINGLE NUCLEOTIDE POLYMORPHISM ON DISEASE SEVERITY OF IRANIAN MULTIPLE SCLEROSIS PATIENTS,” ACTA MEDICA IRANICA, vol. 52, no. 6, pp. 418–423, 2014, [Online]. Available: https://sid.ir/paper/278636/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top