COMPARISON OF INSURE METHOD WITH CONVENTIONAL MECHANICAL VENTILATION AFTER SURFACTANT ADMINISTRATION IN PRETERM INFANTS WITH RESPIRATORY DISTRESS SYNDROME: THERAPEUTIC CHALLENGE

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NAYERI FATEMEH SADAT; ESMAEILNIA SHIRVANI TAHEREH; AMINNEZHAD MAJID; AMINI ELAHEH; DALILI HOSSEIN; MOGHIMPOUR BIJANI FAEZEH

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Journal: ACTA MEDICA IRANICA Year:2014 | Volume:52 | Issue:8 Page(s): 0-0

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Title

COMPARISON OF INSURE METHOD WITH CONVENTIONAL MECHANICAL VENTILATION AFTER SURFACTANT ADMINISTRATION IN PRETERM INFANTS WITH RESPIRATORY DISTRESS SYNDROME: THERAPEUTIC CHALLENGE

Author(s)

Keywords

RDS

CONVENTIONAL MECHANICAL VENTILATION

INSURE

NCPAP

IVH

PDA

SURFACTANT

Abstract

Administration of endotracheal SURFACTANT is potentially the main treatment for neonates suffering from RDS (Respiratory Distress Syndrome), which is followed by mechanical ventilation. Late and severe complications may develop as a consequence of using mechanical ventilation. In this study, conventional methods for treatment of RDS are compared with SURFACTANT administration, use of mechanical ventilation for a brief period and NCPAP (Nasal Continuous Positive Airway Pressure), (INSURE method ((Intubation, SURFACTANT administration and extubation)). A randomized clinical trial study was performed, including all newborn infants with diagnosed RDS and a gestational age of 35 weeks or less, who were admitted in NICU of Valiasr hospital. The patients were then divided randomly into two CMV (Conventional Mechanical Ventilation) and INSURE groups. SURFACTANT administration and consequent long-term mechanical ventilation were done in the first group (CMV group). In the second group (INSURE group), SURFACTANT was administered followed by a short-term period of mechanical ventilation. The infants were then extubated, and NCPAP was embedded. The comparison included crucial duration of mechanical ventilation and oxygen therapy, IVH (Intraventricular Hemorrhage), PDA (Patent Ductus Arteriosus), air-leak syndromes, BPD (Broncho-Pulmonary Dysplasia) and mortality rate. The need for mechanical ventilation in 5th day of admission was 43% decreased (P=0.005) in INSURE group in comparison to CMV group. A decline (P=0.01) in the incidence of IVH and PDA was also achieved. Pneumothorax, chronic pulmonary disease and mortality rates, were not significantly different among two groups. (P=0.25, P=0.14, P=0.25, respectively). This study indicated that INSURE method in the treatment of RDS decreases the need for mechanical ventilation and oxygen-therapy in preterm neonates. Moreover, relevant complications as IVH and PDA were observed to be reduced. Thus, it seems rationale to perform this method as the initial treatment for neonates with mild to moderate RDS.

Cites

SHORT-TERM COMPLICATIONS IN PRETERM INFANTS WITH RESPIRATORY DISTRESS SYNDROME TREATED WITH RAPID EXTUBATION OF TRACHEAL TUBE FOLLOWING ADMINISTRATION OF SURFACTANT (INSURE) AND MECHANICAL VENTILATION METHODS

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APA: Copy

NAYERI, FATEMEH SADAT, ESMAEILNIA SHIRVANI, TAHEREH, AMINNEZHAD, MAJID, AMINI, ELAHEH, DALILI, HOSSEIN, & MOGHIMPOUR BIJANI, FAEZEH. (2014). COMPARISON OF INSURE METHOD WITH CONVENTIONAL MECHANICAL VENTILATION AFTER SURFACTANT ADMINISTRATION IN PRETERM INFANTS WITH RESPIRATORY DISTRESS SYNDROME: THERAPEUTIC CHALLENGE. ACTA MEDICA IRANICA, 52(8), 0-0. SID. https://sid.ir/paper/278660/en

Vancouver: Copy

NAYERI FATEMEH SADAT, ESMAEILNIA SHIRVANI TAHEREH, AMINNEZHAD MAJID, AMINI ELAHEH, DALILI HOSSEIN, MOGHIMPOUR BIJANI FAEZEH. COMPARISON OF INSURE METHOD WITH CONVENTIONAL MECHANICAL VENTILATION AFTER SURFACTANT ADMINISTRATION IN PRETERM INFANTS WITH RESPIRATORY DISTRESS SYNDROME: THERAPEUTIC CHALLENGE. ACTA MEDICA IRANICA[Internet]. 2014;52(8):0-0. Available from: https://sid.ir/paper/278660/en

IEEE: Copy

FATEMEH SADAT NAYERI, TAHEREH ESMAEILNIA SHIRVANI, MAJID AMINNEZHAD, ELAHEH AMINI, HOSSEIN DALILI, and FAEZEH MOGHIMPOUR BIJANI, “COMPARISON OF INSURE METHOD WITH CONVENTIONAL MECHANICAL VENTILATION AFTER SURFACTANT ADMINISTRATION IN PRETERM INFANTS WITH RESPIRATORY DISTRESS SYNDROME: THERAPEUTIC CHALLENGE,” ACTA MEDICA IRANICA, vol. 52, no. 8, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/278660/en

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