COMPARISON OF CIPROFLOXACIN-BASED TRIPLE THERAPY WITH CONVENTIONAL TRIPLE REGIMEN FOR HELICOBACTER PYLORI ERADICATION IN CHILDREN

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FARAHMAND FATEMEH; MOHAMMADI TAYEBEH; NAJAFI MEHRI; FALLAHI GHOLAMHOSEIN; KHODADAD AHMAD; MOTAMED FARZANEH; MARASHI SAYED MAHDI; SHOARAN MARYAM; NABAVIZADEH RAFSANJANI RAHELEH

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Journal: ACTA MEDICA IRANICA Year:2016 | Volume:54 | Issue:6 Page(s): 395-400

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Title

COMPARISON OF CIPROFLOXACIN-BASED TRIPLE THERAPY WITH CONVENTIONAL TRIPLE REGIMEN FOR HELICOBACTER PYLORI ERADICATION IN CHILDREN

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Keywords

HELICOBACTER PYLORI

CHILDREN

ERADICATION

CIPROFLOXACIN

FURAZOLIDONE

Abstract

HELICOBACTER PYLORI infection is a prevalent disease among Iranian CHILDREN. The purpose of this study was to compare the effect of CIPROFLOXACIN and FURAZOLIDONE on eradicating HELICOBACTER PYLORI in Iranian CHILDREN in combination with amoxicillin and omeprazole. In this cohort study, HELICOBACTER PYLORI infection was confirmed by gastroscopy, rapid urease test or pathologic assessments. A total of 66 CHILDREN were randomly enrolled, based on the random number table, and were divided into two groups, first, a combination regimen consisting of CIPROFLOXACIN, amoxicillin, and omeprazole, second, a three-medication regimen consisting of amoxicillin, FURAZOLIDONE, and omeprazole. The effect of both medical regimens on the successful ERADICATION of HELICOBACTER PYLORI infection was assessed and compared. Chi-square test was used for evaluating the association between quantitative variables. All comparisons were made at the significance of P<0.05. Endoscopic tests prior to initiating treatments showed that 66.7% of the patients had a degree of nodularity while peptic ulcer was only observed in one patient. One month after the end of the treatments, ERADICATION of the HELICOBACTER PYLORI infection was reported 87.9% (29.33) in the first group (CAO) and 60.6% (20.33) in the second group (FAO) (P=0.011). It appears that a major advantage of our proposed regimen over others is a lack of wide use of fluoroquinolones for treating CHILDREN’s diseases. Given FDA’s recommendation about the possibility of prescribing CIPROFLOXACIN for infected patients with multidrug resistance, we can use the regimen proposed in this study in patients with resistance to standard treatments.

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APA: Copy

FARAHMAND, FATEMEH, MOHAMMADI, TAYEBEH, NAJAFI, MEHRI, FALLAHI, GHOLAMHOSEIN, KHODADAD, AHMAD, MOTAMED, FARZANEH, MARASHI, SAYED MAHDI, SHOARAN, MARYAM, & NABAVIZADEH RAFSANJANI, RAHELEH. (2016). COMPARISON OF CIPROFLOXACIN-BASED TRIPLE THERAPY WITH CONVENTIONAL TRIPLE REGIMEN FOR HELICOBACTER PYLORI ERADICATION IN CHILDREN. ACTA MEDICA IRANICA, 54(6), 395-400. SID. https://sid.ir/paper/278838/en

Vancouver: Copy

FARAHMAND FATEMEH, MOHAMMADI TAYEBEH, NAJAFI MEHRI, FALLAHI GHOLAMHOSEIN, KHODADAD AHMAD, MOTAMED FARZANEH, MARASHI SAYED MAHDI, SHOARAN MARYAM, NABAVIZADEH RAFSANJANI RAHELEH. COMPARISON OF CIPROFLOXACIN-BASED TRIPLE THERAPY WITH CONVENTIONAL TRIPLE REGIMEN FOR HELICOBACTER PYLORI ERADICATION IN CHILDREN. ACTA MEDICA IRANICA[Internet]. 2016;54(6):395-400. Available from: https://sid.ir/paper/278838/en

IEEE: Copy

FATEMEH FARAHMAND, TAYEBEH MOHAMMADI, MEHRI NAJAFI, GHOLAMHOSEIN FALLAHI, AHMAD KHODADAD, FARZANEH MOTAMED, SAYED MAHDI MARASHI, MARYAM SHOARAN, and RAHELEH NABAVIZADEH RAFSANJANI, “COMPARISON OF CIPROFLOXACIN-BASED TRIPLE THERAPY WITH CONVENTIONAL TRIPLE REGIMEN FOR HELICOBACTER PYLORI ERADICATION IN CHILDREN,” ACTA MEDICA IRANICA, vol. 54, no. 6, pp. 395–400, 2016, [Online]. Available: https://sid.ir/paper/278838/en

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