EVALUATION OF SD-208, A TGF-β-RI KINASE INHIBITOR, AS AN ANTICANCER AGENT IN RETINOBLASTOMA

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FADAKAR PURAN; AKBARI ABOLFAZL; GHASSEMI FARIBA; MOBINI GHOLAMREZA; MOHEBI MASOUMEH; BOLHASSANI MANZAR; ABEDKHOJASTEH HODA; HEIDARI MANSOUR

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Journal: ACTA MEDICA IRANICA Year:2016 | Volume:54 | Issue:6 Page(s): 352-358

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Title

EVALUATION OF SD-208, A TGF-β-RI KINASE INHIBITOR, AS AN ANTICANCER AGENT IN RETINOBLASTOMA

Author(s)

Keywords

MIRNA

RETINOBLASTOMA

SD-208

Y-79 CELL LINE

Abstract

Retinoblastoma is the most common intraocular tumor in children resulting from genetic alterations and transformation of mature retinal cells. The objective of this study was to investigate the effects of SD-208, TGF-b-RI kinase inhibitor, on the expression of some MIRNAs including a miR-17/92 cluster in RETINOBLASTOMA cells. Prior to initiate this work, the cell proliferation was studied by Methyl Thiazolyl Tetrazolium (MTT) and bromo-2′-deoxyuridine (BrdU) assays. Then, the expression patterns of four MIRNAs (18a, 20a, 22, and 34a) were investigated in the treated SD-208 (0.0, 1, 2 and 3 mM) and untreated Y-79 cells. A remarkable inhibition of the cell proliferation was found in Y-79 cells treated with SD-208 versus untreated cells. Also, the expression changes were observed in MIRNAs 18a, 20a, 22 and 34a in response to SD-208 treatment (P<0.05). The findings of the present study suggest that the anti-cancer effect of SD-208 may be exerted due to the regulation of specific MIRNAs, at least in this particular RETINOBLASTOMA cell line. To the best of the researchers’ knowledge, this is the first report demonstrating that the SD-208 could alter the expression of tumor suppressive MIRNAs as well as oncomiRsin vitro. In conclusion, the present data suggest that SD-208 could be an alternative agent in RETINOBLASTOMA treatment.

Cites

THE ROLE OF MICRORNA SIGNATURE AS DIAGNOSTIC BIOMARKERS IN DIFFERENT CLINICAL STAGES OF COLORECTAL CANCER

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APA: Copy

FADAKAR, PURAN, AKBARI, ABOLFAZL, GHASSEMI, FARIBA, MOBINI, GHOLAMREZA, MOHEBI, MASOUMEH, BOLHASSANI, MANZAR, ABEDKHOJASTEH, HODA, & HEIDARI, MANSOUR. (2016). EVALUATION OF SD-208, A TGF-β-RI KINASE INHIBITOR, AS AN ANTICANCER AGENT IN RETINOBLASTOMA. ACTA MEDICA IRANICA, 54(6), 352-358. SID. https://sid.ir/paper/278841/en

Vancouver: Copy

FADAKAR PURAN, AKBARI ABOLFAZL, GHASSEMI FARIBA, MOBINI GHOLAMREZA, MOHEBI MASOUMEH, BOLHASSANI MANZAR, ABEDKHOJASTEH HODA, HEIDARI MANSOUR. EVALUATION OF SD-208, A TGF-β-RI KINASE INHIBITOR, AS AN ANTICANCER AGENT IN RETINOBLASTOMA. ACTA MEDICA IRANICA[Internet]. 2016;54(6):352-358. Available from: https://sid.ir/paper/278841/en

IEEE: Copy

PURAN FADAKAR, ABOLFAZL AKBARI, FARIBA GHASSEMI, GHOLAMREZA MOBINI, MASOUMEH MOHEBI, MANZAR BOLHASSANI, HODA ABEDKHOJASTEH, and MANSOUR HEIDARI, “EVALUATION OF SD-208, A TGF-β-RI KINASE INHIBITOR, AS AN ANTICANCER AGENT IN RETINOBLASTOMA,” ACTA MEDICA IRANICA, vol. 54, no. 6, pp. 352–358, 2016, [Online]. Available: https://sid.ir/paper/278841/en

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