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Information Journal Paper

Title

INTRA-DORSAL HIPPOCAMPAL MICROINJECTIONS OF LITHIUM AND SCOPOLAMINE INDUCE A CROSS STATE-DEPENDENT LEARNING IN MICE

Author(s)

 GHORBAN ALIZADEH KHALIFEH MAHALEH B. | TAHERI SABA | SAHEBGHARANI M. | REZAYOF A. | HAERI ROUHANI SEYED ALI | ZARINDAST M.R. | Issue Writer Certificate 

Pages

  629-638

Abstract

 Background: LITHIUM, a mood stabilizer, may exert adverse effects on memory. We have previously shown that LITHIUM induces STATE-DEPENDENT LEARNING. Cholinergic systems of the brain may play an important role in memory function and mood regulation. In the present study, the effects of intra-dorsal hippocampal (intra-CA1) injections of LITHIUM and SCOPOLAMINE on memory and cross STATE-DEPENDENT LEARNING between the two drugs were investigated.Methods: For memory assessment, a one-trial step-down inhibitory avoidance task was used in adult male NMRI mice.Results: Intra-CA1 administration of LITHIUM (0.5 and 1mg/mouse) after training or injection of the drug (0.5mg/mouse) before testing impaired memory when retrieval was tested 24 hours later. The memory impairment by post-training LITHIUM was reversed by pretest administration of the drug (0.5mg/mouse, intra-CA1) suggesting LITHIUM STATE-DEPENDENT LEARNING. On the other hand, intra-CA1 administration of SCOPOLAMINE (0.5, 1, and 2mg/mouse) after training or injection of the drug (2mg/mouse) before testing impaired memory when retrieval was tested 24 hours later The impairment of memory by post-training injection of SCOPOLAMINE (2mg/mouse) was restored by the pretest injection of the drug (1 and 2mg/mouse). Furthermore, memory impairment induced by post-training injection of LITHIUM (0.5mg/mouse) and SCOPOLAMINE (2mg/mouse) was reversed by pretest administration of SCOPOLAMINE (0.5, 1, and 2mg/mouse) and LITHIUM (0.5 and 1mg/mouse), respectively. The impairment by LITHIUM was also reversed by physostigmine.Conclusion: The results suggest that microinjections of both LITHIUM and SCOPOLAMINE induce state-dependent memory and there may be a cross state-dependency between the two drugs.

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    APA: Copy

    GHORBAN ALIZADEH KHALIFEH MAHALEH, B., TAHERI, SABA, SAHEBGHARANI, M., REZAYOF, A., HAERI ROUHANI, SEYED ALI, & ZARINDAST, M.R.. (2008). INTRA-DORSAL HIPPOCAMPAL MICROINJECTIONS OF LITHIUM AND SCOPOLAMINE INDUCE A CROSS STATE-DEPENDENT LEARNING IN MICE. ARCHIVES OF IRANIAN MEDICINE, 11(6), 629-638. SID. https://sid.ir/paper/280367/en

    Vancouver: Copy

    GHORBAN ALIZADEH KHALIFEH MAHALEH B., TAHERI SABA, SAHEBGHARANI M., REZAYOF A., HAERI ROUHANI SEYED ALI, ZARINDAST M.R.. INTRA-DORSAL HIPPOCAMPAL MICROINJECTIONS OF LITHIUM AND SCOPOLAMINE INDUCE A CROSS STATE-DEPENDENT LEARNING IN MICE. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2008;11(6):629-638. Available from: https://sid.ir/paper/280367/en

    IEEE: Copy

    B. GHORBAN ALIZADEH KHALIFEH MAHALEH, SABA TAHERI, M. SAHEBGHARANI, A. REZAYOF, SEYED ALI HAERI ROUHANI, and M.R. ZARINDAST, “INTRA-DORSAL HIPPOCAMPAL MICROINJECTIONS OF LITHIUM AND SCOPOLAMINE INDUCE A CROSS STATE-DEPENDENT LEARNING IN MICE,” ARCHIVES OF IRANIAN MEDICINE, vol. 11, no. 6, pp. 629–638, 2008, [Online]. Available: https://sid.ir/paper/280367/en

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