GENETIC VARIATION IN NFKB1 GENE INFLUENCES LIVER ENZYME LEVELS IN MORBIDLY OBESE WOMEN

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YENMIS GUVEN; SOYDAS TUGBA; ARKAN HULYA; TASAN ERTUGRUL; SULTUYBEK GONUL KANIGUR

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2018 | Volume:21 | Issue:1 Page(s): 13-18

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Title

GENETIC VARIATION IN NFKB1 GENE INFLUENCES LIVER ENZYME LEVELS IN MORBIDLY OBESE WOMEN

Author(s)

Keywords

LIVER ENZYMES

MORBID OBESITY

NFKB1

POLYMORPHISM

Abstract

Background: MORBID OBESITY (MO), characterized by low-grade inflammation, is associated with increased C-reactive protein (CRP). NF-KB is a candidate factor for inflammatory responses in inflammatory diseases such as obesity. The objective of our study was to investigate the relationship between NFKB1 gene variations and the risk of MO in the context of the high/normal level of LIVER ENZYMES such as Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and alkaline phosphatase (ALP). Methods: We analyzed the distribution of NFKB1-94 ins/del ATTG (rs28362491) POLYMORPHISM using polymerase chain reaction-restriction fragment length POLYMORPHISM (PCR-RFLP) and LIVER ENZYMES serum levels using ELISA in 182 MO patients with CRP level ≥ 20 mg/L and 200 healthy controls in a female Turkish population. Results: We found that having ins/ins genotype of rs28362491 is a risk factor in both high level and normal level LIVER ENZYMES of ALT (P = 0. 0335, P = 0. 0134), AST (P = 0. 0285, P = 0. 0113) and ALP (P = 0. 0079, P = 0. 0363) whereas having ins/ins genotype of rs28362491 is a risk factor in only high-level liver enzyme of GGT (P = 0. 0003). Conclusion: Our results suggest that ins/ins genotype of SNP rs28362491 is linked to MO with high-level ALT, AST, ALP, and GGT.

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APA: Copy

YENMIS, GUVEN, SOYDAS, TUGBA, ARKAN, HULYA, TASAN, ERTUGRUL, & SULTUYBEK, GONUL KANIGUR. (2018). GENETIC VARIATION IN NFKB1 GENE INFLUENCES LIVER ENZYME LEVELS IN MORBIDLY OBESE WOMEN. ARCHIVES OF IRANIAN MEDICINE, 21(1), 13-18. SID. https://sid.ir/paper/281591/en

Vancouver: Copy

YENMIS GUVEN, SOYDAS TUGBA, ARKAN HULYA, TASAN ERTUGRUL, SULTUYBEK GONUL KANIGUR. GENETIC VARIATION IN NFKB1 GENE INFLUENCES LIVER ENZYME LEVELS IN MORBIDLY OBESE WOMEN. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2018;21(1):13-18. Available from: https://sid.ir/paper/281591/en

IEEE: Copy

GUVEN YENMIS, TUGBA SOYDAS, HULYA ARKAN, ERTUGRUL TASAN, and GONUL KANIGUR SULTUYBEK, “GENETIC VARIATION IN NFKB1 GENE INFLUENCES LIVER ENZYME LEVELS IN MORBIDLY OBESE WOMEN,” ARCHIVES OF IRANIAN MEDICINE, vol. 21, no. 1, pp. 13–18, 2018, [Online]. Available: https://sid.ir/paper/281591/en

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