Pericardial Graft vs. Host Disease in a Patient with β-Thalassemia Major

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SARAVI MEHRDAD; VAKILI SADEGHI MOHSEN; MAHMOODI NESHELI HASSAN

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Journal Paper

Paper Information

Journal: ARCHIVES OF IRANIAN MEDICINE Year:2016 | Volume:19 | Issue:9 Page(s): 674-676

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Information Journal Paper

Title

Pericardial Graft vs. Host Disease in a Patient with β-Thalassemia Major

Author(s)

SARAVI MEHRDAD | VAKILI SADEGHI MOHSEN | MAHMOODI NESHELI HASSAN | Issue Writer Certificate

Keywords

BMT

B-thalassemia major

GVHD

HSCT

pericarditis

Abstract

Bone marrow transplantation (BMT) in young children improves results in β-thalassemia major. Graft versus host disease (GVHD) is an important complication of peripheral blood stem cell transplantation. GVHD affects heart with a behavior resembling an autoimmune disease, including pericardial effusion. We describe a 22-year-old β-thalassemia major patient who underwent bone marrow transplantation with an HLA-identical sibling donor. The patient didn’ t have any serious problem until 15 months after transplantation. He presented with chest discomfort and progressive dyspnea. Early echocardiogram showed mild pericardial effusion. Four days later, the effusion had increased, impending to cardiac temponade requiring pericardectomy. Immunospressive drugs and pericardectomy resulted in significant improvement in ventricular filling. Cardiac cGVHD, an un-common complication of HSCT may be presented as pericardial effusion. Although early initiation of steroids is very important, heart monitoring is necessary to diagnose cardiac temponade.

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APA: Copy

SARAVI, MEHRDAD, VAKILI SADEGHI, MOHSEN, & MAHMOODI NESHELI, HASSAN. (2016). Pericardial Graft vs. Host Disease in a Patient with β-Thalassemia Major. ARCHIVES OF IRANIAN MEDICINE, 19(9), 674-676. SID. https://sid.ir/paper/281716/en

Vancouver: Copy

SARAVI MEHRDAD, VAKILI SADEGHI MOHSEN, MAHMOODI NESHELI HASSAN. Pericardial Graft vs. Host Disease in a Patient with β-Thalassemia Major. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2016;19(9):674-676. Available from: https://sid.ir/paper/281716/en

IEEE: Copy

MEHRDAD SARAVI, MOHSEN VAKILI SADEGHI, and HASSAN MAHMOODI NESHELI, “Pericardial Graft vs. Host Disease in a Patient with β-Thalassemia Major,” ARCHIVES OF IRANIAN MEDICINE, vol. 19, no. 9, pp. 674–676, 2016, [Online]. Available: https://sid.ir/paper/281716/en

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