IONOTROPIC GLUTAMATE RECEPTORS AND THEIR ROLE IN NEUROLOGICAL DISEASES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAHRAKI ALI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Kerman University of Medical Sciences Year:2010 | Volume:17 | Issue:4 Page(s): 361-378

Download Full-Text

Persian Verion

View:

3,174

Download:

Cites:

Information Journal Paper

Title

IONOTROPIC GLUTAMATE RECEPTORS AND THEIR ROLE IN NEUROLOGICAL DISEASES

Author(s)

SHAHRAKI ALI | Issue Writer Certificate

Keywords

GLUTAMATESQ3

N- METHYL- D- ASPARTATE RECEPTORSQ3

AMPA RECEPTORSQ3

EXCITOTOXICITYQ3

KAINATE RECEPTORSQ3

GLUTAMATE TRANSPORTERSQ3

Abstract

Glutamate is extensively and relatively uniformly distributed in the central nervous system (CNS) and its effects mediated by two distinct groups of receptors including Ionotropic and metabotropic glutamate receptors. Concentration of glutamate in the nervous system is much higher than in other tissues. Glutamate receptors play an important role in synaptic transmission, neural plasticity and neural development. Although glutamate has various neural physiological effects, it is a strong neurotoxin and high concentration of glutamate in synaptic milieu and extra cellular space plays a critical role in neurodegenerative diseases like ischemia, acute neural trauma and many other CNS disorders.Selective ligands for glutamate receptors have made considerable advances in the identification of the physiological and pathological roles of these receptors in the nervous system. Furthermore, advances in animal models of neurodegenerative disorders have lead to the application of many glutamatergic compounds in clinical studies. These compounds consist of ionotropic glutamate receptor antagonists that examined in clinical tests for disorders including epilepsy, ischemic stroke, etc. The purpose of this review is to describe ionotropic glutamate receptors and their possible roles in EXCITOTOXICITY and nervous system disorders. Then we will discuss briefly about transporters for glutamate and their association in the pathology of CNS disorders. Finally, involvement of ionotropic glutamate receptors in neurological disorders including schizophrenia, Alzheimer's disease and epilepsy will be explained.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAHRAKI, ALI. (2010). IONOTROPIC GLUTAMATE RECEPTORS AND THEIR ROLE IN NEUROLOGICAL DISEASES. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 17(4), 361-378. SID. https://sid.ir/paper/282/en

Vancouver: Copy

SHAHRAKI ALI. IONOTROPIC GLUTAMATE RECEPTORS AND THEIR ROLE IN NEUROLOGICAL DISEASES. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2010;17(4):361-378. Available from: https://sid.ir/paper/282/en

IEEE: Copy

ALI SHAHRAKI, “IONOTROPIC GLUTAMATE RECEPTORS AND THEIR ROLE IN NEUROLOGICAL DISEASES,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 4, pp. 361–378, 2010, [Online]. Available: https://sid.ir/paper/282/en

Related Journal Papers