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Information Journal Paper

Title

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-[2-(2-NAPHTHYL)ETHYL] PIPERAZINYL QUINOLONES

Pages

  325-333

Abstract

 A series of N-[2-(2-naphthyl)ethyl]piperazinyl quinolones containing a carbonyl related functional groups (oxo- or oxyimino-) on the ethyl spacer was synthesized and evaluated for ANTIBACTERIAL ACTIVITY. The synthesis of N-[2-(2-naphthyl)ethyl]piperazinyl quinolones was achieved through the versatile and efficient synthetic route that involved reaction of PIPERAZINYL QUINOLONES with appropriate α-bromoketone or α-bromooxime derivatives. The structures of new compounds were confirmed by elemental analysis, IR and NMR spectra. Antibacterial data indicated that some of the new N-[2-(2-naphthyl)ethyl]piperazinyl quinolones showed good ANTIBACTERIAL ACTIVITY and modification of the position 8 and N-1 substituent on quinolone ring, and ethyl spacer functionality produced significant changes in activity against Gram-positive and Gram-negative bacteria.

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    • Cite

    APA: Copy

    SHAFIEI, A., EMAMI, S., GHODSI, S., NAJARI, S., SORKHI, M., SAMADI, N., FARAMARZI, M.A., & FOROUMADI, A.. (2009). SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-[2-(2-NAPHTHYL)ETHYL] PIPERAZINYL QUINOLONES. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), 6(2), 325-333. SID. https://sid.ir/paper/282298/en

    Vancouver: Copy

    SHAFIEI A., EMAMI S., GHODSI S., NAJARI S., SORKHI M., SAMADI N., FARAMARZI M.A., FOROUMADI A.. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-[2-(2-NAPHTHYL)ETHYL] PIPERAZINYL QUINOLONES. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)[Internet]. 2009;6(2):325-333. Available from: https://sid.ir/paper/282298/en

    IEEE: Copy

    A. SHAFIEI, S. EMAMI, S. GHODSI, S. NAJARI, M. SORKHI, N. SAMADI, M.A. FARAMARZI, and A. FOROUMADI, “SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-[2-(2-NAPHTHYL)ETHYL] PIPERAZINYL QUINOLONES,” JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), vol. 6, no. 2, pp. 325–333, 2009, [Online]. Available: https://sid.ir/paper/282298/en

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