A NOVEL AND EFFICIENT APPROACH FOR THE AMIDATION OF C-TERMINAL PEPTIDES

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ARABANIAN A.; MOHAMMADNEZHAD M.; BALALAEI S.

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ISSN: 2588-4824

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Paper Information

Journal: JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS) Year:2010 | Volume:7 | Issue:4 Page(s): 840-845

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Title

A NOVEL AND EFFICIENT APPROACH FOR THE AMIDATION OF C-TERMINAL PEPTIDES

Author(s)

ARABANIAN A. | MOHAMMADNEZHAD M. | BALALAEI S. | Issue Writer Certificate

Keywords

MET-ENKEPHALIN

LEU-ENKEPHALIN

SOLID PHASE PEPTIDE SYNTHESIS

AMIDATION

C-TERMINAL AMIDATED PEPTIDES

Abstract

highly efficient and practical synthesis of C -terminal amidated peptides has been developed. According to this approach, AMIDATION of the C- terminus of peptides was carried out using NH4Cl, alkylammonium chloride (RNH3Cl) and semicarbazide hydrochloride in the presence of TBTU as a coupling reagent and a tertiary amine as the base at room temperature in good to high yields. Some opioid peptides such as enkephalin derivatives were synthesized according to this novel method.

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APA: Copy

ARABANIAN, A., MOHAMMADNEZHAD, M., & BALALAEI, S.. (2010). A NOVEL AND EFFICIENT APPROACH FOR THE AMIDATION OF C-TERMINAL PEPTIDES. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), 7(4), 840-845. SID. https://sid.ir/paper/282494/en

Vancouver: Copy

ARABANIAN A., MOHAMMADNEZHAD M., BALALAEI S.. A NOVEL AND EFFICIENT APPROACH FOR THE AMIDATION OF C-TERMINAL PEPTIDES. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)[Internet]. 2010;7(4):840-845. Available from: https://sid.ir/paper/282494/en

IEEE: Copy

A. ARABANIAN, M. MOHAMMADNEZHAD, and S. BALALAEI, “A NOVEL AND EFFICIENT APPROACH FOR THE AMIDATION OF C-TERMINAL PEPTIDES,” JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), vol. 7, no. 4, pp. 840–845, 2010, [Online]. Available: https://sid.ir/paper/282494/en

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