COMPARING THE EFFECTS OF CLOMIPHENE-HMG AND LETROZOLE-HMG ON OVULATION INDUCTION IN INFERTILE WOMEN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHAZIZADEH SH.; AMOUEI KHAN ABBASI M.; BAGHERI MARYAM; GHILICHKHANI MARYAM; MASOUMI MASOUMEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Reproduction & Infertility Year:2009 | Volume:10 | Issue:2 (39) Page(s): 109-114

Download Full-Text

Persian Verion

View:

6,076

Download:

Cites:

Information Journal Paper

Title

COMPARING THE EFFECTS OF CLOMIPHENE-HMG AND LETROZOLE-HMG ON OVULATION INDUCTION IN INFERTILE WOMEN

Author(s)

Keywords

CLOMIPHENEQ3

HCGQ2

HMGQ3

IUIQ3

LETROZOLEQ1

OVARIAN HYPERSTIMULATION SYNDROME (OHSS)Q1

OVULATION INDUCTIONQ1

PCODQ1

Abstract

Introduction: CLOMIPHENE Citrate has been one of the effective medications in the treatment of infertility but it has undesirable side effects, such as flushing, decreased cervical mucus production, impaired postcoital test (PCT) and multiple pregnancies. LETROZOLE is a newer drug and it improves cervical mucus production, increases endometrial thickness and reduces the risk for multiple pregnancies. Comparing the efficacy of CLOMIPHENE citrate versus LETROZOLE for OVULATION INDUCTION in patients with Polycystic Ovarian Disease (PCOD) was the objective of this study.Materials and Methods: This clinical trial study was done on 100 infertile, 20-35 year-old women with PCOD attending Vali-e-Asr Infertility Clinic from April 2003 to April 2007. The cases were candidates for intrauterine insemination (IUI) and signed a consent form to participate in the study. The cases were assigned to two groups through simple random sampling, the first group receiving clomiphen citrate plus HMG and the second one LETROZOLE plus HMG. Endometrial thickness, number of mature follicles, pregnancy rates, history of abortion and multiple pregnancies were recorded and compared in the two groups.Results: Comparing the two groups, the number of mature follicles (p=0.000), the risk for ovarian hyperstimulation (40% versus 14%, p=0.003) and abortions rates (37.5% versus 11.11%, p=0.048) were significantly higher in the CLOMIPHENE group. Differences in endometrial thickness and pregnancy rates (eight subjects in the CLOMIPHENE versus nine in the LETROZOLE group) were of no statistical significance in the two groups.Conclusion: It seems that LETROZOLE is a good substitute for CLOMIPHENE citrate, especially in patients at risk of abortion or ovarian hyperstimulation syndrome (OHSS), or in those who cannot tolerate CLOMIPHENE citrate. Further studies are needed to be done to fully suggest LETROZOLE as the first line treatment for controlled ovarian hyperstimulation syndrome.

Cites

No record.

References

Cite

APA: Copy

GHAZIZADEH, SH., AMOUEI KHAN ABBASI, M., BAGHERI, MARYAM, GHILICHKHANI, MARYAM, & MASOUMI, MASOUMEH. (2009). COMPARING THE EFFECTS OF CLOMIPHENE-HMG AND LETROZOLE-HMG ON OVULATION INDUCTION IN INFERTILE WOMEN. JOURNAL OF REPRODUCTION AND INFERTILITY, 10(2 (39)), 109-114. SID. https://sid.ir/paper/28355/en

Vancouver: Copy

GHAZIZADEH SH., AMOUEI KHAN ABBASI M., BAGHERI MARYAM, GHILICHKHANI MARYAM, MASOUMI MASOUMEH. COMPARING THE EFFECTS OF CLOMIPHENE-HMG AND LETROZOLE-HMG ON OVULATION INDUCTION IN INFERTILE WOMEN. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2009;10(2 (39)):109-114. Available from: https://sid.ir/paper/28355/en

IEEE: Copy

SH. GHAZIZADEH, M. AMOUEI KHAN ABBASI, MARYAM BAGHERI, MARYAM GHILICHKHANI, and MASOUMEH MASOUMI, “COMPARING THE EFFECTS OF CLOMIPHENE-HMG AND LETROZOLE-HMG ON OVULATION INDUCTION IN INFERTILE WOMEN,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 10, no. 2 (39), pp. 109–114, 2009, [Online]. Available: https://sid.ir/paper/28355/en

Related Journal Papers