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Information Journal Paper

Title

Magnetic Resonance Spectroscopy of Brain Circuits in Patients with First-Episode Obsessive-Compulsive Disorder (NEURORADIOLOGY)

Pages

  0-0

Abstract

 Background: Obsessive-Compulsive Disorder (OCD) is considered neurodevelopmental disorder that shares the feature of dysfunctional frontal-subcortical circuitry, yet the relationshipbetweenstructural abnormalities or neurobiochemistrical changesandOCD pathogenesis is still unknown. Objectives: This study aims to use Magnetic Resonance Spectroscopy (MRS) to discover substance-metabolism abnormalities of Brain circuits in patients with first-episode OCD, and to study the mechanism of OCD. PatientsandMethods: Twenty patients with first-episodeOCDand twenty gender-and age-matched normal controls were studied. Neurochemical abnormalities, including ratios of N-acetylaspartate (NAA), creatine (Cr), and choline (Cho), were measured in the prefrontal cortex, anterior cingulate cortex, orbitofrontal cortex, caudate nucleus, and thalamus with three-dimensional 1H-proton MRS (3D 1H-MRS). The data of the ratios in the two groups were analyzed with a independent samples t-test. Results: Cho/Cr ratios in the thalamus were significantly higher in the first-episode OCD patients than in the controls (P < 0. 01), and the NAA/Cr ratios in the caudate nucleus and thalamus were significantly lower in the first-episode OCD patients than in the controls (P < 0. 01). However, NAA/Cr ratios in the anterior cingulate cortex and orbitofrontal cortex were higher in the first-episode OCD patients than in the controls (P < 0. 01). Conclusion: Distinct neurochemical and histological structure changes (cortico-striatal-thalamic-cortical cycle) exist in patients with first-episode OCD. 1H-MRS is capable of identifying these changes by assessing metabolic abnormalities.

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    APA: Copy

    CHEN, FENG, GUO, MIN, Liu, Tao, Jiang, Xiang Ling, LI, JIAN JUN, & Guo, Jun Cheng. (2017). Magnetic Resonance Spectroscopy of Brain Circuits in Patients with First-Episode Obsessive-Compulsive Disorder (NEURORADIOLOGY). IRANIAN JOURNAL OF RADIOLOGY, 14(1), 0-0. SID. https://sid.ir/paper/284561/en

    Vancouver: Copy

    CHEN FENG, GUO MIN, Liu Tao, Jiang Xiang Ling, LI JIAN JUN, Guo Jun Cheng. Magnetic Resonance Spectroscopy of Brain Circuits in Patients with First-Episode Obsessive-Compulsive Disorder (NEURORADIOLOGY). IRANIAN JOURNAL OF RADIOLOGY[Internet]. 2017;14(1):0-0. Available from: https://sid.ir/paper/284561/en

    IEEE: Copy

    FENG CHEN, MIN GUO, Tao Liu, Xiang Ling Jiang, JIAN JUN LI, and Jun Cheng Guo, “Magnetic Resonance Spectroscopy of Brain Circuits in Patients with First-Episode Obsessive-Compulsive Disorder (NEURORADIOLOGY),” IRANIAN JOURNAL OF RADIOLOGY, vol. 14, no. 1, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/284561/en

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