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Information Journal Paper

Title

Non-Invasive Assessment of Liver Fibrosis in a Rat Model: Comparison of ShearWave Elastography with Serologic Tests

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Abstract

 Background: Non-invasive evaluation of hepatic Fibrosis, especiallyserumbiomarkersandultrasound elastography, has vigorously developed during the past decades. Objectives: The purpose of this study was to evaluate the diagnostic performance of the latest generation of ultrasound elastography-two-dimensional real-time shear wave elastography (SWE) in accessing liver Fibrosis progression in comparison with Serologic Tests in a rat model. Materials and Methods: Liver Fibrosis was induced in 108 rats (control group: 18 rats, experiment group: 90 rats) by intraperitoneal injection of thioacetamide (300mg/kg, twice a week for 12 weeks). SWE examination was done by two operators. Hyaluronic acid (HA), aspartate aminotransferase (AST) to platelet (PLT) ratio index (APRI), AST to alanine aminotransferase (ALT) ratio (AAR) were used for serology tests. Histological Fibrosis stages (F0-F4) according to the Scheuer scoring system were referred as the gold standard. Diagnostic performance of elastography and serology methods were determined by the areas under receiver operating characteristic curve (AUROC). Results: Liver stiffness values increased with the progression of hepatic Fibrosis. Liver stiffness assessed by SWE exhibited a strong positive correlation with histological Fibrosis stages (r = 0. 849, P < 0. 001). SWE showed a better diagnostic performance than the selected serological biomarkers HA, APRI, and AAR (AUROC for SWE, HA, APRI, and AAR were 0. 933, 0. 707, 0. 714, and 0. 691 in diagnosing F F2 and 0. 986, 0. 807, 0. 870, and 0. 770 in diagnosing F = F4, respectively). Conclusion: Ultrasound elastographySWEtechnique is a reliable method for noninvasive evaluation of liver Fibrosis in comparison with the serological biomarkers, HA, APRI, and AAR.

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    APA: Copy

    Yue, Zhang, Hong, Ding, Peili, Fan, Yuli, Zhu, Yuan, Zhuang, Wenjiao, Zeng, & Wenping, Wang. (2018). Non-Invasive Assessment of Liver Fibrosis in a Rat Model: Comparison of ShearWave Elastography with Serologic Tests. IRANIAN JOURNAL OF RADIOLOGY, 15(3), 0-0. SID. https://sid.ir/paper/284835/en

    Vancouver: Copy

    Yue Zhang, Hong Ding, Peili Fan, Yuli Zhu, Yuan Zhuang, Wenjiao Zeng, Wenping Wang. Non-Invasive Assessment of Liver Fibrosis in a Rat Model: Comparison of ShearWave Elastography with Serologic Tests. IRANIAN JOURNAL OF RADIOLOGY[Internet]. 2018;15(3):0-0. Available from: https://sid.ir/paper/284835/en

    IEEE: Copy

    Zhang Yue, Ding Hong, Fan Peili, Zhu Yuli, Zhuang Yuan, Zeng Wenjiao, and Wang Wenping, “Non-Invasive Assessment of Liver Fibrosis in a Rat Model: Comparison of ShearWave Elastography with Serologic Tests,” IRANIAN JOURNAL OF RADIOLOGY, vol. 15, no. 3, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/284835/en

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