INHIBITING EFFECTS OF METFORMIN ON OVARIAN HYPERSTIMULATION SYNDROME (OHSS) IN INDUCTION OF OVULATION WITH GONADOTROPIN IN ART CYCLES ON WOMEN WITH POLYCYSTIC OVARY SYNDROME (PCOS)

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AGHA HOSSINEI M.; ALE YASIN ASHRAF; KHALILI M.

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Journal Paper

Paper Information

Journal: Journal of Reproduction & Infertility Year:2001 | Volume:2 | Issue:2 (6) Page(s): 42-47

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Title

INHIBITING EFFECTS OF METFORMIN ON OVARIAN HYPERSTIMULATION SYNDROME (OHSS) IN INDUCTION OF OVULATION WITH GONADOTROPIN IN ART CYCLES ON WOMEN WITH POLYCYSTIC OVARY SYNDROME (PCOS)

Author(s)

AGHA HOSSINEI M. | ALE YASIN ASHRAF | KHALILI M. | Issue Writer Certificate

Keywords

METFORMINQ3

OVARIAN HYPERSTIMULATION SYNDROME (OHSS)Q3

POLYCYSTIC OVARY SYNDROME (PCOS)Q3

INDUCTION OVULATIONQ3

ARTQ4

Abstract

In this research, it is supposed that treatment with METFORMIN prior to ovulation induction with gonadotropins in ART cycles, would be able to prevent OHSS and its severity among women with PCOS. This study was a randomized clinical trial on 100 women with PCOS who were treated in ART cycles. These women were divided randomly in two groups A and B (50 subjects each). Group A received 500 mg of METFORMIN daily for about one month before INDUCTION OVULATION with HMG and continued this treatment for about 45 days . Induction of ovulation protocol (classic long protocol) was similar in both groups. At the end of study the following results were compared in both groups: The serum Estradiol (E2) level on day of HCG administration and HMG doses (daily and total) were significantly lower in group A (P<0.002 and P<0.001 respectively). The number of women with OHSS and its severity and the number of admission in group A were lower than group B (P<0.001 and P<0.02, respectively), but the numbers of oocyte, pregnancy and the duration of treatment with HMG were similar in both groups. These results show that METFORMIN by reducing resistance to insulin and hyperandrogenism, leads to reduction in E2 level and favors orderly follicular growth in response to exogenous gonadotropin and it reduces the risk and severity of OHSS.

Cites

EVALUATION OF IMPAIRED GLUCOSE TOLERANCE TEST IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME

References

EFFECTS OF METFORMIN ON SPONTANEOUS AND CLOMIPHEN INDUCED OVULATION IN THE POLYCYSTIC OVARY SYNDROME

Cite

APA: Copy

AGHA HOSSINEI, M., ALE YASIN, ASHRAF, & KHALILI, M.. (2001). INHIBITING EFFECTS OF METFORMIN ON OVARIAN HYPERSTIMULATION SYNDROME (OHSS) IN INDUCTION OF OVULATION WITH GONADOTROPIN IN ART CYCLES ON WOMEN WITH POLYCYSTIC OVARY SYNDROME (PCOS). JOURNAL OF REPRODUCTION AND INFERTILITY, 2(2 (6)), 42-47. SID. https://sid.ir/paper/28588/en

Vancouver: Copy

AGHA HOSSINEI M., ALE YASIN ASHRAF, KHALILI M.. INHIBITING EFFECTS OF METFORMIN ON OVARIAN HYPERSTIMULATION SYNDROME (OHSS) IN INDUCTION OF OVULATION WITH GONADOTROPIN IN ART CYCLES ON WOMEN WITH POLYCYSTIC OVARY SYNDROME (PCOS). JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2001;2(2 (6)):42-47. Available from: https://sid.ir/paper/28588/en

IEEE: Copy

M. AGHA HOSSINEI, ASHRAF ALE YASIN, and M. KHALILI, “INHIBITING EFFECTS OF METFORMIN ON OVARIAN HYPERSTIMULATION SYNDROME (OHSS) IN INDUCTION OF OVULATION WITH GONADOTROPIN IN ART CYCLES ON WOMEN WITH POLYCYSTIC OVARY SYNDROME (PCOS),” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 2, no. 2 (6), pp. 42–47, 2001, [Online]. Available: https://sid.ir/paper/28588/en

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