DIFFERENT ASPECTS OF CYTOCHALASIN B BLOCKED MICRONUCLEUS CYTOME (CBMN CYT) ASSAY AS A COMPREHENSIVE MEASUREMENT TOOL FOR RADIOBIOLOGICAL STUDIES, BIOLOGICAL DOSIMETRY AND GENOME INSTABILITY

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SALIMI MAHDIEH; MOZDARANI H.

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Journal: International Journal of Radiation Research Year:2015 | Volume:13 | Issue:2 Page(s): 101-126

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Title

DIFFERENT ASPECTS OF CYTOCHALASIN B BLOCKED MICRONUCLEUS CYTOME (CBMN CYT) ASSAY AS A COMPREHENSIVE MEASUREMENT TOOL FOR RADIOBIOLOGICAL STUDIES, BIOLOGICAL DOSIMETRY AND GENOME INSTABILITY

Author(s)

SALIMI MAHDIEH | MOZDARANI H. | Issue Writer Certificate

Keywords

CYTOME ASSAY

MICRONUCLEUS

GENOME INSTABILITY

RADIOBIOLOGICAL STUDIES

BIOLOGICAL DOSIM

Abstract

It is now universally accepted that DNA is the main target for damages caused by physical and chemical genotoxicants. Although there are different methods to measure directly the induced DNA damages but due to fast repair processes in cellular environment, most of the damages would be repaired even before sampling, therefore processed DNA damages, i.e. damages left unrepaired after acting repair machinery is preferable to measure in various exposure scenarios. Various cytogenetic end points are introduced and implemented such as metaphase analysis, sister chromatid exchanges, premature chromosome condensation, translocation assay and MICRONUCLEUS assay. All of these methods were extensively used for various purposes but among them MICRONUCLEUS (MN) assay was found more practical because of ease of scoring, potential for automation as well as being nearly as sensitive as other procedures. These characteristics made MN assay very popular for screening of the effects of various genotoxic agents in vitro and in vivo. In this review we try to summarize the main aspects of application of this method in RADIOBIOLOGICAL STUDIES and GENOME INSTABILITY related diseases.

Cites

Comparative study of chemo-sensitivity expressed as micronuclei in lymphocytes of breast cancer patients, their unaffected first degree relatives and normal controls as a possible prognostic marker

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APA: Copy

SALIMI, MAHDIEH, & MOZDARANI, H.. (2015). DIFFERENT ASPECTS OF CYTOCHALASIN B BLOCKED MICRONUCLEUS CYTOME (CBMN CYT) ASSAY AS A COMPREHENSIVE MEASUREMENT TOOL FOR RADIOBIOLOGICAL STUDIES, BIOLOGICAL DOSIMETRY AND GENOME INSTABILITY. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 13(2), 101-126. SID. https://sid.ir/paper/286624/en

Vancouver: Copy

SALIMI MAHDIEH, MOZDARANI H.. DIFFERENT ASPECTS OF CYTOCHALASIN B BLOCKED MICRONUCLEUS CYTOME (CBMN CYT) ASSAY AS A COMPREHENSIVE MEASUREMENT TOOL FOR RADIOBIOLOGICAL STUDIES, BIOLOGICAL DOSIMETRY AND GENOME INSTABILITY. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2015;13(2):101-126. Available from: https://sid.ir/paper/286624/en

IEEE: Copy

MAHDIEH SALIMI, and H. MOZDARANI, “DIFFERENT ASPECTS OF CYTOCHALASIN B BLOCKED MICRONUCLEUS CYTOME (CBMN CYT) ASSAY AS A COMPREHENSIVE MEASUREMENT TOOL FOR RADIOBIOLOGICAL STUDIES, BIOLOGICAL DOSIMETRY AND GENOME INSTABILITY,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 13, no. 2, pp. 101–126, 2015, [Online]. Available: https://sid.ir/paper/286624/en

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