PREDICTIVE VALUES OF TNF-α, IL-6, IL-10 FOR RADIATION PNEUMONITIS

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LI B.; CHEN S.H.; LU HAI JUN; TAN Y.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Radiation Research Year:2016 | Volume:14 | Issue:3 Page(s): 173-179

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Information Journal Paper

Title

PREDICTIVE VALUES OF TNF-α, IL-6, IL-10 FOR RADIATION PNEUMONITIS

Author(s)

LI B. | CHEN S.H. | LU HAI JUN | TAN Y. | Issue Writer Certificate

Keywords

RADIATION PNEUMONITIS

TUMOR NECROSIS FACTOR–α

INTERLEUKIN-6

INTERLEUKIN-10

LUNG CANCER

Abstract

Background: To investigate the expression of TNF-a, IL-6, IL-10 in the plasma of patients with LUNG CANCER who received radiation therapy (RT), and to analyze the correlation between these cytokines and RADIATION PNEUMONITIS (RP).Materials and Methods: Patients with LUNG CANCER who received 3D-CRT in our hospital were prospectively evaluated. Circulating cytokine levels were measured with ELISA before RT and at the end of RT. Regular follow-up was undertaken 3 months after RT. Statistical analysis was applied to determine the relevance of cytokines to radiation-induced lung injury.Results: Of 104 patients, 29 (27.9%) developed RP. The levels of TNF-a and IL-6 levels in the plasma after RT were significantly higher than before RT (p<0.05), whereas IL -10 levels were significantly lower after RT than before RT (p<0.05). Before RT, TNF-a levels were higher in RP group (p<0.05), but there were no differences in TNF-a levels after RT. No association was observed between IL-6 and IL-10 levels and the risk of RP. Univariate analysis showed that baseline pulmonary function, smoking history, histopathology, lung volume receiving ≥20 Gy (V20), Mean lung dose (MLD) and total radiation dose were related to RP, but only MLD was an independent risk factor for RP in LUNG CANCER patients (OR>1).Conclusion: TNF-a levels in plasma were closely related to RP but still cannot be used as predictors for RP.

Cites

Anti-inflammatory role of piperine against rat lung tissue damage induced by gamma-rays

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APA: Copy

LI, B., CHEN, S.H., LU, HAI JUN, & TAN, Y.. (2016). PREDICTIVE VALUES OF TNF-α, IL-6, IL-10 FOR RADIATION PNEUMONITIS. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 14(3), 173-179. SID. https://sid.ir/paper/286722/en

Vancouver: Copy

LI B., CHEN S.H., LU HAI JUN, TAN Y.. PREDICTIVE VALUES OF TNF-α, IL-6, IL-10 FOR RADIATION PNEUMONITIS. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2016;14(3):173-179. Available from: https://sid.ir/paper/286722/en

IEEE: Copy

B. LI, S.H. CHEN, HAI JUN LU, and Y. TAN, “PREDICTIVE VALUES OF TNF-α, IL-6, IL-10 FOR RADIATION PNEUMONITIS,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 14, no. 3, pp. 173–179, 2016, [Online]. Available: https://sid.ir/paper/286722/en

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