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Information Journal Paper

Title

Anti-inflammatory role of piperine against rat lung tissue damage induced by gamma-rays

Pages

  75-84

Abstract

 Background: Radiation‐ induced acute lung damages are refractory side effects in lung cancer radiotherapy (RT). Prospective study investigates the possible role of piperine (Pip) as anti-inflammatory agent against γ-rays-induced lung tissue lesions in an applicable rat model. Materials and Methods: Fifty-six Sprague-Dawley rats were divided into four groups: Control, rats were administered the vehicle by gastric tube for 6-weeks, Pip-treated, (each rat received 40mg Pip/kg body-weight; once daily, orally for 6weeks), irradiated, (animals subjected to a single dose of whole body γ-rays (12Gy), and Pip-treated & irradiated, (each rat received the Pip-dosages, then one hour later after the last treatment, rats were exposed to 12Gy γ-rays. Results: The administration of Pip to rats pre-irradiation was significantly abolish the radiation-induced alleviation in lungs catalase (CAT) and glutathione peroxidase (PGx) activities and reduced glutathione (GSH) content and significantly limited the elevation in serum tumor necrosis factor-α (TNF-α ), interleukin-1β (IL-1β ) and interleukin-6 (IL-6) levels compared to irradiated group. The histopathological findings in lung tissues of irradiated group, showed partial desquamation of bronchiolar epithelial with peri-bronchiolar round cell infiltration and serous exudates, in some cases lung presented sero-fibrinous pneumonia with emphysema and collapse of some alveoli with thickness of inter-alveolar septa, while in Pip-treated & irradiated group, lung tissues showed minimum injury with or without few degenerative changes. Conclusion: Pip acts as a potent scavenger of free radicals to prevent and/or ameliorates the harmful effects of γ-rays. To our knowledge, this is the preliminary report of Pip mediated γ-rays induced lung inflammation in-vitro.

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    APA: Copy

    Elkady, a.a., & Tawfik, s.s.. (2018). Anti-inflammatory role of piperine against rat lung tissue damage induced by gamma-rays. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 16(1), 75-84. SID. https://sid.ir/paper/286764/en

    Vancouver: Copy

    Elkady a.a., Tawfik s.s.. Anti-inflammatory role of piperine against rat lung tissue damage induced by gamma-rays. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2018;16(1):75-84. Available from: https://sid.ir/paper/286764/en

    IEEE: Copy

    a.a. Elkady, and s.s. Tawfik, “Anti-inflammatory role of piperine against rat lung tissue damage induced by gamma-rays,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 16, no. 1, pp. 75–84, 2018, [Online]. Available: https://sid.ir/paper/286764/en

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