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Information Journal Paper

Title

Radiobiological and physical effects of patient setup errors during whole breast irradiation

Pages

  343-352

Abstract

 Background: The dose-related effects of pa ent Setup errors on bio-physical indices were evaluated for the conven onal wedge (CW) and field-in-field (FIF) whole breast irradia on techniques (WBI). Materials and Methods: The treatment plans of 10 pa ents receiving le' WBI were retrospec vely selected for evalua on. The bio-physical effects of dose varia ons were evaluated by shi'ing the isocenters and gantry-angles of the treatment plans. Dose-volume histograms of the planning target volume (PTV), heart, and lungs were generated, and the conformity index (CI), homogeneity index (HI), tumor control probability (TCP), and normal  ssue complica on probability (NTCP) were determined. Results: The D95 of the PTV for an “ isocenter shi' plan” with a posterior direc on decreased by approximately 15%, and the TCP of the PTV decreased by approximately 50% for the FIF technique and by 40% for the CW; however, the NTCPs of the lungs and heart increased for both techniques. Increasing the gantry-angle decreased the TCPs of the PTV by 24. 4% (CW) and by 34% (FIF). The NTCPs of the lungs and heart for the two techniques differed by only 3%. The CIs and HIs for the CW case were higher than the corresponding values obtained for the FIF case. Significant differences were observed between the two techniques (p<0. 01). Conclusion: Our results revealed that the biophysical proper es of the FIF case were more sensi ve to Setup errors than those in the CW case. The radiobiological-based analysis could be detected significant dosimetric errors and provided a prac cal pa ent quality assurance method for guiding the bio-physical effects.

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  • Cite

    APA: Copy

    LEE, S.R., KIM, M.J., PARK, S.H., LEE, M.Y., & Suh, t.s.. (2017). Radiobiological and physical effects of patient setup errors during whole breast irradiation. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 15(4), 343-352. SID. https://sid.ir/paper/286893/en

    Vancouver: Copy

    LEE S.R., KIM M.J., PARK S.H., LEE M.Y., Suh t.s.. Radiobiological and physical effects of patient setup errors during whole breast irradiation. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2017;15(4):343-352. Available from: https://sid.ir/paper/286893/en

    IEEE: Copy

    S.R. LEE, M.J. KIM, S.H. PARK, M.Y. LEE, and t.s. Suh, “Radiobiological and physical effects of patient setup errors during whole breast irradiation,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 15, no. 4, pp. 343–352, 2017, [Online]. Available: https://sid.ir/paper/286893/en

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