PREPARATION AND EVALUATION OF ACECLOFENAC TOPICAL MICROEMULSION

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SHAH R.R.; MAGDUM C.S.; PATIL SH.SH.; NIAKWADE N.SH.

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Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2010 | Volume:9 | Issue:1 Page(s): 5-11

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Title

PREPARATION AND EVALUATION OF ACECLOFENAC TOPICAL MICROEMULSION

Author(s)

SHAH R.R. | MAGDUM C.S. | PATIL SH.SH. | NIAKWADE N.SH. | Issue Writer Certificate

Keywords

ACECLOFENAC

TOPICAL MICROEMULSION

SKIN PERMEATION

PHASE DIAGRAM

PERCUTANEOUS DELIVERY

Abstract

A topical preparation containing ACECLOFENAC was developed using an o/w microemulsion system. Isopropyl myristate was chosen as the oil phase as it showed a good solubilising capacity. Pseudo-ternary PHASE DIAGRAMs were used to obtain the concentration ranges of the oil, surfactant (Labrasol) and co-surfactant (plurol oleique) for microemulsion formation. Five different formulations were formulated with various amount of the oil (5-25%), water (10-50%), and the mixture of surfactant and co-surfactant at the ratio of 4 (45-65%). In vitro permeability of ACECLOFENAC from the microemulsions was evaluated using Keshary Chien diffusion cells with 0.45-mm cellulose acetate membrane. The amount of the ACECLOFENAC permeated was analyzed by HPLC and the droplet size and zeta potential of the microemulsions was determined using a Zetasizer Nano-ZS. The mean diameters of the microemulsion droplets approximately ranged between 154 - 434 nm, and the permeability of ACECLOFENAC incorporated into the microemulsion systems was 3 folds higher than that of the marketed formulation. These results indicate that the microemulsion system studied is a promising tool for PERCUTANEOUS DELIVERY of ACECLOFENAC.

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APA: Copy

SHAH, R.R., MAGDUM, C.S., PATIL, SH.SH., & NIAKWADE, N.SH.. (2010). PREPARATION AND EVALUATION OF ACECLOFENAC TOPICAL MICROEMULSION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 9(1), 5-11. SID. https://sid.ir/paper/287772/en

Vancouver: Copy

SHAH R.R., MAGDUM C.S., PATIL SH.SH., NIAKWADE N.SH.. PREPARATION AND EVALUATION OF ACECLOFENAC TOPICAL MICROEMULSION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2010;9(1):5-11. Available from: https://sid.ir/paper/287772/en

IEEE: Copy

R.R. SHAH, C.S. MAGDUM, SH.SH. PATIL, and N.SH. NIAKWADE, “PREPARATION AND EVALUATION OF ACECLOFENAC TOPICAL MICROEMULSION,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 9, no. 1, pp. 5–11, 2010, [Online]. Available: https://sid.ir/paper/287772/en

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