FORMULATION OF TOPICAL BIOADHESIVE GEL OF ACECLOFENAC USING 3-LEVEL FACTORIAL DESIGN

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SINGH SANJAY; PARHI RABINARAYAN; GARG ANUJ

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Journal: Iranian Journal of Pharmaceutical Research Year:2011 | Volume:10 | Issue:3 Page(s): 435-445

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Title

FORMULATION OF TOPICAL BIOADHESIVE GEL OF ACECLOFENAC USING 3-LEVEL FACTORIAL DESIGN

Author(s)

SINGH SANJAY | PARHI RABINARAYAN | GARG ANUJ | Issue Writer Certificate

Keywords

TOPICAL BIOADHESIVE GEL

ACECLOFENAC

THREE-LEVEL FACTORIAL DESIGN

DESIGN

HPMC

Abstract

The objective of this work was to develop bioadhesive topical gel of ACECLOFENAC with the help of response-surface approach. Experiments were performed according to a 3-level factorial DESIGN to evaluate the effects of two independent variables [amount of Poloxamer 407 (PL-407 =X1) and hydroxypropylmethyl cellulose K100 M (HPMC=X2)] on the bioadhesive character of gel, rheological property of gel (consistency index), and in-vitro drug release. The best model was selected to fit the data. Mathematical equation was generated by DESIGN Expert® software for the model which assists in determining the effect of independent variables. Response surface plots were also generated by the software for analyzing effect of the independent variables on the response. Quadratic model was found to be the best for all the responses. Both independent variable (X1 and X2) were found to have synergistic effect on bioadhesion (Y1) but the effect of HPMC was more pronounced than PL-407. Consistency index was enhanced by increasing the level of both independent variables. An antagonistic effect of both independent variables was found on cumulative percentage release of drug in 2 (Y3) and 8 h (Y4). Both independent variables approximately equally contributed the antagonistic effect on Y3 whereas antagonistic effect of HPMC was more pronounced than PL-407.The effect of formulation variables on the product characteristics can be easily predicted and precisely interpreted by using a 3-level factorial experimental DESIGN and generated quadratic mathematical equations.

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APA: Copy

SINGH, SANJAY, PARHI, RABINARAYAN, & GARG, ANUJ. (2011). FORMULATION OF TOPICAL BIOADHESIVE GEL OF ACECLOFENAC USING 3-LEVEL FACTORIAL DESIGN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 10(3), 435-445. SID. https://sid.ir/paper/287858/en

Vancouver: Copy

SINGH SANJAY, PARHI RABINARAYAN, GARG ANUJ. FORMULATION OF TOPICAL BIOADHESIVE GEL OF ACECLOFENAC USING 3-LEVEL FACTORIAL DESIGN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2011;10(3):435-445. Available from: https://sid.ir/paper/287858/en

IEEE: Copy

SANJAY SINGH, RABINARAYAN PARHI, and ANUJ GARG, “FORMULATION OF TOPICAL BIOADHESIVE GEL OF ACECLOFENAC USING 3-LEVEL FACTORIAL DESIGN,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 10, no. 3, pp. 435–445, 2011, [Online]. Available: https://sid.ir/paper/287858/en

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