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Information Journal Paper

Title

ANTIOXIDANT AND CYTOTOXIC ACTIVITIES AND PHYTOCHEMICAL ANALYSIS OF EUPHORBIA WALLICHII ROOT EXTRACT AND ITS FRACTIONS

Pages

  241-249

Abstract

 Euphorbia wallichiia perennial herb growing mainly in Himalayas has been widely used in folk medicines for its medicinal properties. In the present study, the crude methanolic root extract (CME) and its fractions; n-Hexane Fraction (NHF), n-Butanol Fraction (NBF), Chloroform Fraction (CHF), Ethyl acetate Fraction (EAF) and Aqueous Fraction (AQF) of this plant specie were investigated for ANTIOXIDANT and cytotoxic activities and PHYTOCHEMICAL ANALYSIS. ANTIOXIDANT activity was determined by using 2, 2-diphenyl-1-picryl-hydrazyl free radical (DPPH) and DNA PROTECTION assay performed on pBR322 plasmid DNA. In both these assays, promising results were obtained for CME as well as other fractions. The IC50 values for DPPH assay were in a range of 7.89 to 63.35 mg/ml in which EAF showed the best anti-oxidant potential and almost all the tested samples showed certain level of DNA PROTECTION. The cytotoxic activity was assessed by using Sulforhodamine B (SRB) assay on human cell lines; H157 (Lung Carcinoma) and HT144 (Malignant Melanoma). The IC50 values of the tested samples ranged from 0.18 to 1.4 mg/mL against H157 cell line whereas against HT144 cell line the IC50 values ranged from 0.46 to 17.88 mg/mL with NBF fraction showing maximum potential for both. Furthermore, the PHYTOCHEMICAL ANALYSIS of CME and its fractions showed the presences of flavonoids, saponins, tannins, terpenoides and cardiac glycosides with varying concentrations.

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    • Cite

    APA: Copy

    HAQ LU, IHSAN, ULLAH, NAZIF, BIBI, GULNAZ, KANWAL, SIMAB, AHMAD, MUHAMMAD SHEERAZ, & MIRZA, BUSHRA. (2012). ANTIOXIDANT AND CYTOTOXIC ACTIVITIES AND PHYTOCHEMICAL ANALYSIS OF EUPHORBIA WALLICHII ROOT EXTRACT AND ITS FRACTIONS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(1), 241-249. SID. https://sid.ir/paper/287923/en

    Vancouver: Copy

    HAQ LU IHSAN, ULLAH NAZIF, BIBI GULNAZ, KANWAL SIMAB, AHMAD MUHAMMAD SHEERAZ, MIRZA BUSHRA. ANTIOXIDANT AND CYTOTOXIC ACTIVITIES AND PHYTOCHEMICAL ANALYSIS OF EUPHORBIA WALLICHII ROOT EXTRACT AND ITS FRACTIONS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(1):241-249. Available from: https://sid.ir/paper/287923/en

    IEEE: Copy

    IHSAN HAQ LU, NAZIF ULLAH, GULNAZ BIBI, SIMAB KANWAL, MUHAMMAD SHEERAZ AHMAD, and BUSHRA MIRZA, “ANTIOXIDANT AND CYTOTOXIC ACTIVITIES AND PHYTOCHEMICAL ANALYSIS OF EUPHORBIA WALLICHII ROOT EXTRACT AND ITS FRACTIONS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 1, pp. 241–249, 2012, [Online]. Available: https://sid.ir/paper/287923/en

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