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Title

THE EFFECTS OF BERBERIS VULGARIS FRUIT EXTRACT ON SERUM LIPOPROTEINS, APOB, APOA-I, HOMOCYSTEINE, GLYCEMIC CONTROL AND TOTAL ANTIOXIDANT CAPACITY IN TYPE 2 DIABETIC PATIENTS

Pages

  643-652

Abstract

 Type 2 DIABETES is a well-known endocrine and metabolic disorder which has reached epidemic proportions worldwide and represents a serious public health concern. Hyperglycemia and dyslipidemia are two major abnormalities which are major cardiovascular risk factors. Berberine is a major alkaloid in BERBERIS VULGARIS fruit extract (BVFE) which have important role in regulation of serum glucose and fat metabolism in-vivo and in-vitro but its role in type 2 DIABETES have not been extensively examined.The aim of this study was the effect of BVFE on serum LIPOPROTEINS, APOB, APOA-I, homocysteine, glycemic control and total ANTIOXIDANT capacity in type 2 diabetic patients. In a double-blind randomised clinical trial, 31 diabetic patients were randomly assigned to 3 g/d BVFE or placebo for 3 months. Serum glucose, LIPOPROTEINS, APOB, APOA-I, insulin, homocysteine and HbA1c were measured at the baseline and also at the end of the 3rd month.At the beginning and end of 1st, 2nd and 3rd months, a 24-h dietary recall questionnaire about each patients was completed. Data were analyzed by SPSS version 16.There were significant decreases in serum TG, TC, LDL-c, apo B, glucose, and insulin and also a significant increase in TAC at the end of the study in BVFE group compared to thecontrol group (p=0.001, p=0.001, p=0.001, p=0.001, p=0.002, p=0.01 and p=0.0001 respectively).There were significant differences in serum TG (p=0.0001), TC (p=0.001), LDL-c (p=0.001), APOB (p=0.001), glucose (p=0.002), insulin (p=0.01), TAC (p=0.005), and insulinresistance (p=0.01) between the two groups at the end of the study; but homocysteine, HbA1c and HDL-c showed no significant changes between the two groups at the end of study. The intake of 3 g/d BVFE for 3 months may have benefical effects on LIPOPROTEINS, apoproteins, glycemic control and TAC in type 2 diabetic patients.

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    APA: Copy

    SHIDFAR, FARZAD, SEYYED EBRAHIMI, SHIMA, HOSSEINI, SHARIEH, HEYDARI, IRAJ, SHIDFAR, SHAHRZAD, & HAJHASSANI, GITI. (2012). THE EFFECTS OF BERBERIS VULGARIS FRUIT EXTRACT ON SERUM LIPOPROTEINS, APOB, APOA-I, HOMOCYSTEINE, GLYCEMIC CONTROL AND TOTAL ANTIOXIDANT CAPACITY IN TYPE 2 DIABETIC PATIENTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(2), 643-652. SID. https://sid.ir/paper/287971/en

    Vancouver: Copy

    SHIDFAR FARZAD, SEYYED EBRAHIMI SHIMA, HOSSEINI SHARIEH, HEYDARI IRAJ, SHIDFAR SHAHRZAD, HAJHASSANI GITI. THE EFFECTS OF BERBERIS VULGARIS FRUIT EXTRACT ON SERUM LIPOPROTEINS, APOB, APOA-I, HOMOCYSTEINE, GLYCEMIC CONTROL AND TOTAL ANTIOXIDANT CAPACITY IN TYPE 2 DIABETIC PATIENTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(2):643-652. Available from: https://sid.ir/paper/287971/en

    IEEE: Copy

    FARZAD SHIDFAR, SHIMA SEYYED EBRAHIMI, SHARIEH HOSSEINI, IRAJ HEYDARI, SHAHRZAD SHIDFAR, and GITI HAJHASSANI, “THE EFFECTS OF BERBERIS VULGARIS FRUIT EXTRACT ON SERUM LIPOPROTEINS, APOB, APOA-I, HOMOCYSTEINE, GLYCEMIC CONTROL AND TOTAL ANTIOXIDANT CAPACITY IN TYPE 2 DIABETIC PATIENTS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 2, pp. 643–652, 2012, [Online]. Available: https://sid.ir/paper/287971/en

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