FLAVONOL GLYCOSIDES FROM EUPHORBIA MICROSCIADIA BIOSS. WITH THEIR IMMUNOMODULATORY ACTIVITIES

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GHANADIANA SYED MUSTAFA; AYATOLLAHI ABDUL MAJID; AFSHARYPUOR SULEIMAN; HAREEM SUMAIRA; ABDALLA OMER MOHAMED; KEZETAS BANKEU JEAN JULES

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Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:3 Page(s): 925-930

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Title

FLAVONOL GLYCOSIDES FROM EUPHORBIA MICROSCIADIA BIOSS. WITH THEIR IMMUNOMODULATORY ACTIVITIES

Author(s)

Keywords

EUPHORBIA MICROSCIADIA

FLAVONOIDS

IMMUNOMODULATORY ACTIVITY

FLAVONOL GLYCOSIDES

Abstract

Four known FLAVONOIDS: quercetin 3-O -b-D-rutinoside (Q3Rut), myricetin 3- O -b-D-galactopyranoside (M3Gal), quercetin 3- O -b-D-galactopyranoside (Q3Gal) and quercetin 3- O -b-D-glucopyranoside (Q3Glc), for the first time were isolated from aerial parts of EUPHORBIA MICROSCIADIA. The chemical structure of them was elucidated on the basis of 1 and 2 D-NMR spectra and different spectroscopic techniques. The immunomodulatory activities of isolated compounds were compared using standard T-cell proliferation assay. These data showed that lymphocyte suppression activity of FLAVONOIDS (1-4) were comparatively lower than prednisolon as a standard drug. Immunosuppressive activity of FLAVONOIDS with hydroxyl groups at both 3′-and 4′-positions in their B-ring (Q3Gal) were more than those with 3′-, 4′-and 5′-hydroxyl substitution (M3Gal). In these compounds, Q3Gal showed the most inhibitory activity, whereas M3Gal showed the least lymphocyte antiprolifeartive activity.

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APA: Copy

GHANADIANA, SYED MUSTAFA, AYATOLLAHI, ABDUL MAJID, AFSHARYPUOR, SULEIMAN, HAREEM, SUMAIRA, ABDALLA, OMER MOHAMED, & KEZETAS BANKEU, JEAN JULES. (2012). FLAVONOL GLYCOSIDES FROM EUPHORBIA MICROSCIADIA BIOSS. WITH THEIR IMMUNOMODULATORY ACTIVITIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(3), 925-930. SID. https://sid.ir/paper/287992/en

Vancouver: Copy

GHANADIANA SYED MUSTAFA, AYATOLLAHI ABDUL MAJID, AFSHARYPUOR SULEIMAN, HAREEM SUMAIRA, ABDALLA OMER MOHAMED, KEZETAS BANKEU JEAN JULES. FLAVONOL GLYCOSIDES FROM EUPHORBIA MICROSCIADIA BIOSS. WITH THEIR IMMUNOMODULATORY ACTIVITIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(3):925-930. Available from: https://sid.ir/paper/287992/en

IEEE: Copy

SYED MUSTAFA GHANADIANA, ABDUL MAJID AYATOLLAHI, SULEIMAN AFSHARYPUOR, SUMAIRA HAREEM, OMER MOHAMED ABDALLA, and JEAN JULES KEZETAS BANKEU, “FLAVONOL GLYCOSIDES FROM EUPHORBIA MICROSCIADIA BIOSS. WITH THEIR IMMUNOMODULATORY ACTIVITIES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 3, pp. 925–930, 2012, [Online]. Available: https://sid.ir/paper/287992/en

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