CYTOTOXIC FLAVONOID GLYCOSIDES FROM RAPISTRUM RUGOSUM L.

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AL TAWEELA AREEJ MOHAMED; FAWZY GHADA AHMED; PERVEEN SHAGUFTA

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:3 Page(s): 839-844

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Information Journal Paper

Title

CYTOTOXIC FLAVONOID GLYCOSIDES FROM RAPISTRUM RUGOSUM L.

Author(s)

AL TAWEELA AREEJ MOHAMED | FAWZY GHADA AHMED | PERVEEN SHAGUFTA | Issue Writer Certificate

Keywords

SRB CYTOTOXIC ASSAY

RAPISTRUM RUGOSUM

FLAVONOID GLYCOSIDES

N-BUTANOL

Abstract

Five FLAVONOID GLYCOSIDES were isolated from then -butanol soluble fraction of the ethanolic extract of RAPISTRUM RUGOSUM and their structures were assigned from 1H- and 13C-NMR spectra (DEPT) with 2D NMR as quercetin-3- O-a-L-rhamnopyranoside (1), quercetin-3- O-b-D-xyloside (2), quercetin, 3-O-a- L-arabinopyranoside, 7- O-a-L-rhamnopyranoside (3), kaempferol 3- O-a-L-arabinopyranoside, 7- O-a-L-rhamnopyranoside (4) and rutin (5). The SRB CYTOTOXIC ASSAY was used to investigate the antitumor activities of n -butanol extract, compound 3 and its hexaacetate 3a, for the first time. Compounds 3 and 3a showed cytotoxic activity against the human cancer cell line, namely, HepG2 (hepatocellular carcinoma cell line) with IC50 (concentration of compound required to reduce cell survival by 50%) 0.86 mg/mL and 3.50 mg/mL, respectively. These results proved that compound 3, the major flavonoid of the n -butanol soluble fraction, has significant cytotoxic activity compared with the standard antitumor drug doxorubicin (0.60 mg/mL).

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APA: Copy

AL TAWEELA, AREEJ MOHAMED, FAWZY, GHADA AHMED, & PERVEEN, SHAGUFTA. (2012). CYTOTOXIC FLAVONOID GLYCOSIDES FROM RAPISTRUM RUGOSUM L.. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(3), 839-844. SID. https://sid.ir/paper/287997/en

Vancouver: Copy

AL TAWEELA AREEJ MOHAMED, FAWZY GHADA AHMED, PERVEEN SHAGUFTA. CYTOTOXIC FLAVONOID GLYCOSIDES FROM RAPISTRUM RUGOSUM L.. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(3):839-844. Available from: https://sid.ir/paper/287997/en

IEEE: Copy

AREEJ MOHAMED AL TAWEELA, GHADA AHMED FAWZY, and SHAGUFTA PERVEEN, “CYTOTOXIC FLAVONOID GLYCOSIDES FROM RAPISTRUM RUGOSUM L.,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 3, pp. 839–844, 2012, [Online]. Available: https://sid.ir/paper/287997/en

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