EFFECT OF FORMULATION VARIABLES ON RIFAMPICIN LOADED ALGINATE BEADS

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NARRA KISHORE; DHANALEKSHMI UNNIKRISHNAN; RANGARAJ GOVINDARAJ; RAJA DEVENDIRAN; SENTHIL KUMAR CELLADURAI; NEELAKANTA REDDY PULLY; BARAN MANDAL ASIT

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Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:3 Page(s): 715-721

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Title

EFFECT OF FORMULATION VARIABLES ON RIFAMPICIN LOADED ALGINATE BEADS

Author(s)

Keywords

RIFAMPICIN

SODIUM ALGINATE

PVP

PVA

Abstract

The present work investigated the preparation of biodegradable beads with alginate polymer by ionotropic gelation method to improve the control release properties of the antibiotic RIFAMPICIN. Ionotropic gelation method was applied to prepare beads using calcium chloride (CaCl2) as cationic component and alginate as an anionic component. In this method, adding 0.5% w/v polyvinyl alcohol (PVA) to SODIUM ALGINATE (3.0% w/v) and 2% w/v of polyvinyl pyrrolidone (PVP) to the CaCl2 solution were maintained to study the drug-loading and its released characteristics. The results showed that the addition of PVA and PVP significantly improved drug-loading, encapsulation efficiency and release characteristics. This demonstrates that the ionic gelation of alginate molecules offers a flexible and easily controllable process.

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APA: Copy

NARRA, KISHORE, DHANALEKSHMI, UNNIKRISHNAN, RANGARAJ, GOVINDARAJ, RAJA, DEVENDIRAN, SENTHIL KUMAR, CELLADURAI, NEELAKANTA REDDY, PULLY, & BARAN MANDAL, ASIT. (2012). EFFECT OF FORMULATION VARIABLES ON RIFAMPICIN LOADED ALGINATE BEADS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(3), 715-721. SID. https://sid.ir/paper/287998/en

Vancouver: Copy

NARRA KISHORE, DHANALEKSHMI UNNIKRISHNAN, RANGARAJ GOVINDARAJ, RAJA DEVENDIRAN, SENTHIL KUMAR CELLADURAI, NEELAKANTA REDDY PULLY, BARAN MANDAL ASIT. EFFECT OF FORMULATION VARIABLES ON RIFAMPICIN LOADED ALGINATE BEADS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(3):715-721. Available from: https://sid.ir/paper/287998/en

IEEE: Copy

KISHORE NARRA, UNNIKRISHNAN DHANALEKSHMI, GOVINDARAJ RANGARAJ, DEVENDIRAN RAJA, CELLADURAI SENTHIL KUMAR, PULLY NEELAKANTA REDDY, and ASIT BARAN MANDAL, “EFFECT OF FORMULATION VARIABLES ON RIFAMPICIN LOADED ALGINATE BEADS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 3, pp. 715–721, 2012, [Online]. Available: https://sid.ir/paper/287998/en

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