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Information Journal Paper

Title

RELATION BETWEEN PROEPILEPTIC ACTIVITY OF INDOMETHACIN AND ADRENAL GLAND HORMONES

Pages

  939-948

Abstract

 The role of inflammation has been shown in the pathogenesis of EPILEPSY, while glucocorticoids and ADRENALINE have anti-inflammatory effects. The aim of the present study was to investigate the effects of ADRENALINE, prednisolone, and INDOMETHACIN on caffeine-induced EPILEPSY (epileptiform activity) in RATs and to examine the mechanism of the pro-epileptic effect of INDOMETHACIN. The adrenalectomized RATs that had been given only ADRENALINE (the control group) did not die; however, ADRENALINE did not prevent the adrenalectomized RATs which were given prazosin, phenoxybenzamine, yohimbine, metoprolol, and propranolol from dying. In the RATs given propranolol+adrenaline, the RATe of death was 100%, while this RATe was 50% in the groups receiving prazosin+adrenaline, phenoxybenzamine+adrenaline, and metoprolol+adrenaline. The RATe was 75% in the group given yohimbine+adrenaline. Prednisolone increased the degree of convulsion in adrenalectomized RATs. Over-reduction in the blood catecholamine level made epileptogenesis more severe. It was observed that ADRENALINE pressed epileptogenesis via its own receptors (a- 1, a- 2, b- 1, b- 2). It was also revealed that all of the adrenergic receptors were responsible due to antiepileptic activity; b- 2 receptors played the most important role. It was observed that both acute and chronic INDOMETHACIN administration reduced the catecholamine levels. The situation in which acute administration of INDOMETHACIN did not affect epileptogenesis might originate from the fact that the structure of INDOMETHACIN did not significantly increase the CORTICOSTERONE level.

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    • Cite

    APA: Copy

    HACIMUFTUOGLU, AHMET, SULEYMAN, HALIS, CADIRCI, ELIF, POLAT, BEYZAGUL, HAKAN ALP, HAMIT, & HALICI, ZEKAI. (2012). RELATION BETWEEN PROEPILEPTIC ACTIVITY OF INDOMETHACIN AND ADRENAL GLAND HORMONES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(3), 939-948. SID. https://sid.ir/paper/288005/en

    Vancouver: Copy

    HACIMUFTUOGLU AHMET, SULEYMAN HALIS, CADIRCI ELIF, POLAT BEYZAGUL, HAKAN ALP HAMIT, HALICI ZEKAI. RELATION BETWEEN PROEPILEPTIC ACTIVITY OF INDOMETHACIN AND ADRENAL GLAND HORMONES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(3):939-948. Available from: https://sid.ir/paper/288005/en

    IEEE: Copy

    AHMET HACIMUFTUOGLU, HALIS SULEYMAN, ELIF CADIRCI, BEYZAGUL POLAT, HAMIT HAKAN ALP, and ZEKAI HALICI, “RELATION BETWEEN PROEPILEPTIC ACTIVITY OF INDOMETHACIN AND ADRENAL GLAND HORMONES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 3, pp. 939–948, 2012, [Online]. Available: https://sid.ir/paper/288005/en

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