مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

BCL-2 AND BAX EXPRESSION IN SKIN FLAPS TREATED WITH FINASTERIDE OR AZELAIC ACID

Pages

  1285-1290

Abstract

 Despite all modern surgical techniques, skin flap that is considered as the main method inmost reconstructive surgeries puts the skin tissue at danger of necrosis and APOPTOSIS derived from ischemia. Therefore, finding a treatment for decreasing the APOPTOSIS derived from flap ischemia will be useful in clinic.In present study, we evaluated the effect of AZELAIC ACID 20% and FINASTERIDE on expression of BCL-2 and bax proteins after the skin flap surgery. For this purpose, 21 rats were entered in three groups including control, AZELAIC ACID 20% and FINASTERIDE, all experienced skin flap surgery and then flap tissue was assessed for determining the expression of proteins in 5 slicesprepared from each rat that were graded between – to+++scales.Both AZELAIC ACID and FINASTERIDE increased the expression of BCL-2 protein (p<0.05) and decrease the expression of bax protein (p<0.05).These results suggested an antiapoptotic role for FINASTERIDE and AZELAIC ACID in preserving the flap after the ischemia reperfusion insult.

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    • Cite

    APA: Copy

    AYATOLLAHI, SEYYED ABDULMAJID, AJAMI, MARJAN, REYHANFARD, HAMED, ASADI, YASIN, NASSIRI KASHANI, MANSOUR, RASHIGHI FIROOZABADI, MEHDI, DAVOODI, SAYED HOSSEIN, HABIBI, ESMAEIL, & PAZOKI TOROUDI, HAMIDREZA. (2012). BCL-2 AND BAX EXPRESSION IN SKIN FLAPS TREATED WITH FINASTERIDE OR AZELAIC ACID. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(4), 1285-1290. SID. https://sid.ir/paper/288028/en

    Vancouver: Copy

    AYATOLLAHI SEYYED ABDULMAJID, AJAMI MARJAN, REYHANFARD HAMED, ASADI YASIN, NASSIRI KASHANI MANSOUR, RASHIGHI FIROOZABADI MEHDI, DAVOODI SAYED HOSSEIN, HABIBI ESMAEIL, PAZOKI TOROUDI HAMIDREZA. BCL-2 AND BAX EXPRESSION IN SKIN FLAPS TREATED WITH FINASTERIDE OR AZELAIC ACID. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(4):1285-1290. Available from: https://sid.ir/paper/288028/en

    IEEE: Copy

    SEYYED ABDULMAJID AYATOLLAHI, MARJAN AJAMI, HAMED REYHANFARD, YASIN ASADI, MANSOUR NASSIRI KASHANI, MEHDI RASHIGHI FIROOZABADI, SAYED HOSSEIN DAVOODI, ESMAEIL HABIBI, and HAMIDREZA PAZOKI TOROUDI, “BCL-2 AND BAX EXPRESSION IN SKIN FLAPS TREATED WITH FINASTERIDE OR AZELAIC ACID,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 4, pp. 1285–1290, 2012, [Online]. Available: https://sid.ir/paper/288028/en

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