مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

353
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

262
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

2

Information Journal Paper

Title

HYPOGLYCEMIC EFFECTS OF THREE MEDICINAL PLANTS IN EXPERIMENTAL DIABETES: INHIBITION OF RAT INTESTINAL α-GLUCOSIDASE AND ENHANCED PANCREATIC INSULIN AND CARDIAC GLUT-4 MRNAS EXPRESSION

Pages

  387-397

Keywords

PBG 

Abstract

 Garlic (Allium sativum L., Alliaceae), Persian shallot (Allium ascalonicum L., Alliaceae) and Sage (Salvia officinalis L., Lamiaceae) are believed to have hypoglycemic properties and have been used traditionally as antidiabetic herbal medicines in Iran. In this study, DIABETES was induced by subcutaneous injection of alloxan monohydrate (100 mg kg-1) to male Wistar rats. Antidiabetic effects of methanolic extracts of the above mentioned three plants on alloxandiabetic rats was investigated in comparison with the effects of antidiabetic drugs such as acarbose, glibenclamide and metformin by measuring postprandial blood glucose (PBG), oral glucose tolerance test (OGTT), inhibition of rat intestinal a-glucosidase enzymes activities and pancreatic INSULIN and cardiac GLUT-4 mRNAs expression. In short term period, hypoglycemic effects of A. sativum and A. ascalonicum showed significant reduction of PBG similar to glibenclamide (5 mg kg-1 bw) while S. officinalis significantly reduced PBG similar to acarbose (20 mg kg-1 bw). After 3 weeks of treatment by methanolic plant extracts, significant chronic decrease in the PBG was observed similar to metformin (100 mg kg-1 bw). For OGTT, S. officinalis reduced PBG in a similar way as acarbose (20 mg kg-1 bw). Intestinal sucrase and maltase activities were inhibited significantly by A. sativum, A. ascalonicum and S. officinalis. In addition, we observed increased expression of INSULIN and GLUT-4 genes in diabetic rats treated with these plants extracts. Up regulation of INSULIN and GLUT-4 genes expression and inhibition of α-glucosidaseactivities are the two mechanisms that play a considerable role in hypoglycemic action of garlic, shallot and sage.

Cites

References

  • No record.

    • Cite

    APA: Copy

    MORADABADI, LEILA, MONTASSER KOUHSARI, SHIDEH, & FEHRESTI SANI, MOHAMMAD. (2013). HYPOGLYCEMIC EFFECTS OF THREE MEDICINAL PLANTS IN EXPERIMENTAL DIABETES: INHIBITION OF RAT INTESTINAL α-GLUCOSIDASE AND ENHANCED PANCREATIC INSULIN AND CARDIAC GLUT-4 MRNAS EXPRESSION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(3), 387-397. SID. https://sid.ir/paper/288126/en

    Vancouver: Copy

    MORADABADI LEILA, MONTASSER KOUHSARI SHIDEH, FEHRESTI SANI MOHAMMAD. HYPOGLYCEMIC EFFECTS OF THREE MEDICINAL PLANTS IN EXPERIMENTAL DIABETES: INHIBITION OF RAT INTESTINAL α-GLUCOSIDASE AND ENHANCED PANCREATIC INSULIN AND CARDIAC GLUT-4 MRNAS EXPRESSION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(3):387-397. Available from: https://sid.ir/paper/288126/en

    IEEE: Copy

    LEILA MORADABADI, SHIDEH MONTASSER KOUHSARI, and MOHAMMAD FEHRESTI SANI, “HYPOGLYCEMIC EFFECTS OF THREE MEDICINAL PLANTS IN EXPERIMENTAL DIABETES: INHIBITION OF RAT INTESTINAL α-GLUCOSIDASE AND ENHANCED PANCREATIC INSULIN AND CARDIAC GLUT-4 MRNAS EXPRESSION,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 3, pp. 387–397, 2013, [Online]. Available: https://sid.ir/paper/288126/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button