VALIDATING A STABILITY INDICATING HPLC METHOD FOR KINETIC STUDY OF CETIRIZINE DEGRADATION IN ACIDIC AND OXIDATIVE CONDITIONS

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SOURI EFFAT; HATAMI ALI; SHABANI RAVARI NAZANIN; ALVANDIFAR FARHAD; BARAZANDEH TEHRANI MALIHEH

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:2 Page(s): 287-294

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Information Journal Paper

Title

VALIDATING A STABILITY INDICATING HPLC METHOD FOR KINETIC STUDY OF CETIRIZINE DEGRADATION IN ACIDIC AND OXIDATIVE CONDITIONS

Author(s)

Keywords

CETIRIZINE

HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC)

DEGRADATION

KINETICS

STABILITY

Abstract

A STABILITY indicating High-Performance Liquid Chromatography (HPLC) method was validated and used to study the DEGRADATION of CETIRIZINE dihydrochloride in acidic and oxidative conditions. The separation was carried out on a Symmetry C18 column and a mixture of 50 mM KH2PO4 and acetonitrile (60:40 v/v, pH=3.5) was used as the mobile phase. The method was linear over the range of 1-20 mg/mL of CETIRIZINE dihydrochloride (r2>0.999) and the within-day and between-day precision values were less than 1.5%. The results showed that CETIRIZINE dihydrochloride was unstable in 2 M HCl and 0.5% H2O2. The KINETICS of the acidic DEGRADATION showed a pseudo-first-order reaction in the temperature range of 70-900C. In addition, the KINETICS of hydrogen peroxide mediated DEGRADATION was pseudo-first-order in the temperature range of 50-800C.

Cites

A STABILITY INDICATING HPLC METHOD FOR THE DETERMINATION OF FLUVOXAMINE IN PHARMACEUTICAL DOSAGE FORMS

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Cite

APA: Copy

SOURI, EFFAT, HATAMI, ALI, SHABANI RAVARI, NAZANIN, ALVANDIFAR, FARHAD, & BARAZANDEH TEHRANI, MALIHEH. (2013). VALIDATING A STABILITY INDICATING HPLC METHOD FOR KINETIC STUDY OF CETIRIZINE DEGRADATION IN ACIDIC AND OXIDATIVE CONDITIONS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(2), 287-294. SID. https://sid.ir/paper/288156/en

Vancouver: Copy

SOURI EFFAT, HATAMI ALI, SHABANI RAVARI NAZANIN, ALVANDIFAR FARHAD, BARAZANDEH TEHRANI MALIHEH. VALIDATING A STABILITY INDICATING HPLC METHOD FOR KINETIC STUDY OF CETIRIZINE DEGRADATION IN ACIDIC AND OXIDATIVE CONDITIONS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(2):287-294. Available from: https://sid.ir/paper/288156/en

IEEE: Copy

EFFAT SOURI, ALI HATAMI, NAZANIN SHABANI RAVARI, FARHAD ALVANDIFAR, and MALIHEH BARAZANDEH TEHRANI, “VALIDATING A STABILITY INDICATING HPLC METHOD FOR KINETIC STUDY OF CETIRIZINE DEGRADATION IN ACIDIC AND OXIDATIVE CONDITIONS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 2, pp. 287–294, 2013, [Online]. Available: https://sid.ir/paper/288156/en

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