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Information Journal Paper

Title

EFFICACY OF RECTAL MISOPROSTOL FOR PREVENTION OF POSTPARTUM HEMORRHAGE

Pages

  469-474

Abstract

 Postpartum hemorrhage is an important cause of maternal morbidity and mortality after delivery. Active management of POSTPARTUM HEMORRHAGE by an uterotonic DRUG decreases the rate of POSTPARTUM HEMORRHAGE. The aim of this study is to evaluate the efficacy of rectal MISOPROSTOL for prevention of POSTPARTUM HEMORRHAGE. This double blind randomized clinical trial was performed on full term pregnant women candidate for vaginal delivery, referred to Zahedan Imam Ali Hospital during 2008-2009. They were randomly divided into two groups of rectal MISOPROSTOL and OXYTOCIN. The women in MISOPROSTOL group received 400 mg rectal MISOPROSTOL after delivery and the women in OXYTOCIN group received 3 IU OXYTOCIN in 1 L ringer serum, intravenously. Rate of bleeding, need to any surgery interventions, rate of transfusion and changes in hemoglobin and hematocrite were compared between two groups. A total of 400 patients (200 cases in MISOPROSTOL group and 200 in OXYTOCIN group) entered to the study. Rate of bleeding>500 cc was significantly higher in OXYTOCIN group than MISOPROSTOL group (33% vs.19%) (p=0.005). Also, need to excessive OXYTOCIN for management of POSTPARTUM HEMORRHAGE was significantly lower in MISOPROSTOL group than OXYTOCIN group (18% vs.30%) (p=0.003). Decrease in hematocrite was significantly more observed in OXYTOCIN group than MISOPROSTOL group (mean decrease of hematocrite was 1.3 ±1.6 in MISOPROSTOL group and 1.6±2.2 in OXYTOCIN group). Two groups were similar in terms of side-effects. Rectal MISOPROSTOL as an uterotonic DRUG can decrease POSTPARTUM HEMORRHAGE and also can prevent from decrease of hemoglobin as compared to OXYTOCIN.

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    • Cite

    APA: Copy

    MIRTEIMOURI, MASOUMEH, TARA, FATEMEH, TEIMOURI, BATOOL, SAKHAVAR, NAHID, & VAEZI, AFSANEH. (2013). EFFICACY OF RECTAL MISOPROSTOL FOR PREVENTION OF POSTPARTUM HEMORRHAGE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(2), 469-474. SID. https://sid.ir/paper/288158/en

    Vancouver: Copy

    MIRTEIMOURI MASOUMEH, TARA FATEMEH, TEIMOURI BATOOL, SAKHAVAR NAHID, VAEZI AFSANEH. EFFICACY OF RECTAL MISOPROSTOL FOR PREVENTION OF POSTPARTUM HEMORRHAGE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(2):469-474. Available from: https://sid.ir/paper/288158/en

    IEEE: Copy

    MASOUMEH MIRTEIMOURI, FATEMEH TARA, BATOOL TEIMOURI, NAHID SAKHAVAR, and AFSANEH VAEZI, “EFFICACY OF RECTAL MISOPROSTOL FOR PREVENTION OF POSTPARTUM HEMORRHAGE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 2, pp. 469–474, 2013, [Online]. Available: https://sid.ir/paper/288158/en

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