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Information Journal Paper

Title

EXTRACTION AND DETERMINATION OF CYPROHEPTADINE IN HUMAN URINE BY DLLME-HPLC METHOD

Pages

  311-318

Abstract

 Novel dispersive liquid-liquid microextraction (DLLME), coupled with high performance liquid chromatography with photodiode array detection (HPLC-DAD) has been applied for the extraction and determination of CYPROHEPTADINE (CPH), an ANTIHISTAMINE, in HUMAN URINE samples. In this method, 0.6 mL of acetonitrile (disperser solvent) containing 30 mL of carbon tetrachloride (extraction solvent) was rapidly injected by a syringe into 5 mL urine sample. After centrifugation, the sedimented phase containing enriched analyte was dissolved in acetonitrile and an aliquot of this solution injected into the HPLC system for analysis. Development of DLLME procedure includes optimization of some important parameters such as kind and volume of extraction and disperser solvent, pH and salt addition. The proposed method has good linearity in the range of 0.02-4.5mg mL-1 and low detection limit (13.1 ng mL-1). The repeatability of the method, expressed as relative standard deviation was 4.9% (n=3). This method has also been applied to the analysis of real urine samples with satisfactory relative recoveries in the range of 91.6-101.0%.

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    APA: Copy

    MAHAM, MEHDI, KIAROSTAMI, VAHID, HUSAIN, SYED WAQIF, ABROOMAND AZAR, PARVIZ, TEHRANI, MOHAMMAD SABER, KHOEINI SHARIFABADI, MALIHE, AFROUZI, HOSSEIN, SHAPOURI, MAHMOUDREZA, & KARAMI OSBOO, ROUHOLLAH. (2013). EXTRACTION AND DETERMINATION OF CYPROHEPTADINE IN HUMAN URINE BY DLLME-HPLC METHOD. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(2), 311-318. SID. https://sid.ir/paper/288160/en

    Vancouver: Copy

    MAHAM MEHDI, KIAROSTAMI VAHID, HUSAIN SYED WAQIF, ABROOMAND AZAR PARVIZ, TEHRANI MOHAMMAD SABER, KHOEINI SHARIFABADI MALIHE, AFROUZI HOSSEIN, SHAPOURI MAHMOUDREZA, KARAMI OSBOO ROUHOLLAH. EXTRACTION AND DETERMINATION OF CYPROHEPTADINE IN HUMAN URINE BY DLLME-HPLC METHOD. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(2):311-318. Available from: https://sid.ir/paper/288160/en

    IEEE: Copy

    MEHDI MAHAM, VAHID KIAROSTAMI, SYED WAQIF HUSAIN, PARVIZ ABROOMAND AZAR, MOHAMMAD SABER TEHRANI, MALIHE KHOEINI SHARIFABADI, HOSSEIN AFROUZI, MAHMOUDREZA SHAPOURI, and ROUHOLLAH KARAMI OSBOO, “EXTRACTION AND DETERMINATION OF CYPROHEPTADINE IN HUMAN URINE BY DLLME-HPLC METHOD,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 2, pp. 311–318, 2013, [Online]. Available: https://sid.ir/paper/288160/en

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