A CONVENIENT SIMPLE METHOD FOR SYNTHESIS OF META-IODOBENZYLGUANIDINE (MIBG)

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SHEIKHOLISLAM ZAHRA; SOLEIMANI ZOHREH; MOGHIMI ABOLGHASEM; SHAHHOSSEINI SORAYA

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:4 Page(s): 729-733

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Title

A CONVENIENT SIMPLE METHOD FOR SYNTHESIS OF META-IODOBENZYLGUANIDINE (MIBG)

Author(s)

SHEIKHOLISLAM ZAHRA | SOLEIMANI ZOHREH | MOGHIMI ABOLGHASEM | SHAHHOSSEINI SORAYA | Issue Writer Certificate

Keywords

META-IODOBENZYLGUANIDINE

NEUROENDOCRINE TUMORS

SYMPATHETIC NEURONS

RADIOIODINATED MIBG

Abstract

Radioiodinated META-IODOBENZYLGUANIDINE (MIBG) is one of the important radiopharmaceuticals in Nuclear Medicine. [123/131I] MIBG is used for imaging of Adrenal medulla, studying heart sympathetic nerves, treatment of pheochromacytoma and neuroblastoma. For clinical application, RADIOIODINATED MIBG is prepared through isotopic exchange method, which includes replacement of radioactive iodine in a nucleophilic substitution reaction with cold iodine (127I). The unlabelled MIBG hemisulfate is synthesized by the procedure described by Wieland et al. (1980). The availability of a more practical and cost-effective procedure for MIBG preparation encouraged us to study the MIBG synthesis methods. In this study the preparation of MIBG through different methods were evaluated and a new method, which is one step, simple and cost-effective is introduced. The method has ability to be scaled up for production of unlabelled MIBG.

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APA: Copy

SHEIKHOLISLAM, ZAHRA, SOLEIMANI, ZOHREH, MOGHIMI, ABOLGHASEM, & SHAHHOSSEINI, SORAYA. (2013). A CONVENIENT SIMPLE METHOD FOR SYNTHESIS OF META-IODOBENZYLGUANIDINE (MIBG). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(4), 729-733. SID. https://sid.ir/paper/288186/en

Vancouver: Copy

SHEIKHOLISLAM ZAHRA, SOLEIMANI ZOHREH, MOGHIMI ABOLGHASEM, SHAHHOSSEINI SORAYA. A CONVENIENT SIMPLE METHOD FOR SYNTHESIS OF META-IODOBENZYLGUANIDINE (MIBG). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(4):729-733. Available from: https://sid.ir/paper/288186/en

IEEE: Copy

ZAHRA SHEIKHOLISLAM, ZOHREH SOLEIMANI, ABOLGHASEM MOGHIMI, and SORAYA SHAHHOSSEINI, “A CONVENIENT SIMPLE METHOD FOR SYNTHESIS OF META-IODOBENZYLGUANIDINE (MIBG),” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 4, pp. 729–733, 2013, [Online]. Available: https://sid.ir/paper/288186/en

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