مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EFFECT OF SINGLE DOSE ADMINISTRATION OF METHYLSULFONYLMETHANE ON OXIDATIVE STRESS FOLLOWING ACUTE EXHAUSTIVE EXERCISE

Pages

  845-853

Abstract

 Methylsulfonylmethane (MSM) is a sulfur-containing compound commonly found in diet and known to reduce oxidative stress. This trial was conducted to determine whether single dose supplementation with MSM attenuates post-exercise oxidative stress in healthy untrained young men. Sixteen untrained men volunteered for this study. Participants were randomized in a double-blind placebo-controlled fashion into 2 groups: Methylsulfonylmethane (MSM) (n=8) and placebo (n=8). The participants took supplementation or placebo before running on treadmill for 45 min at 75% VO2max. The MSM supplementation was prepared in water as 100 mg/ kg body weight. The placebo group received water. Serum Malondealdehyde (MDA), URIC ACID, BILIRUBIN, protein carbonyl (PC) and plasma vitamin E levels were determined as the markers of oxidative stress. Plasma GSH (reduced Glutathione) and total ANTIOXIDANT capacity (TAC) were measured as markers of plasma ANTIOXIDANT system. MSM supplementation successfully lowered serum PC 2 and 24 h after exercise. Plasma TAC in MSM group was higher at 24 h after exercise. Serum level of URIC ACID and BILIRUBIN were significantly low immediately after exercise in MSM supplemented group. There was no significant difference between groups in terms of plasma GSH level. These results complement earlier studies showing anti-oxidant effect of MSM and suggest that single dose oral supplementation with MSM lowers exercise induced oxidative stress in healthy untrained young men, but is not adequate to significantly affect plasma GSH level.

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    APA: Copy

    NAKHOSTIN ROOHI, BABAK, NIKNAM, ZAHRA, VAEZI, NASRIN, MOHAMMADI, SADOLLAH, & BOHLOOLI, SHAHAB. (2013). EFFECT OF SINGLE DOSE ADMINISTRATION OF METHYLSULFONYLMETHANE ON OXIDATIVE STRESS FOLLOWING ACUTE EXHAUSTIVE EXERCISE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(4), 845-853. SID. https://sid.ir/paper/288210/en

    Vancouver: Copy

    NAKHOSTIN ROOHI BABAK, NIKNAM ZAHRA, VAEZI NASRIN, MOHAMMADI SADOLLAH, BOHLOOLI SHAHAB. EFFECT OF SINGLE DOSE ADMINISTRATION OF METHYLSULFONYLMETHANE ON OXIDATIVE STRESS FOLLOWING ACUTE EXHAUSTIVE EXERCISE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(4):845-853. Available from: https://sid.ir/paper/288210/en

    IEEE: Copy

    BABAK NAKHOSTIN ROOHI, ZAHRA NIKNAM, NASRIN VAEZI, SADOLLAH MOHAMMADI, and SHAHAB BOHLOOLI, “EFFECT OF SINGLE DOSE ADMINISTRATION OF METHYLSULFONYLMETHANE ON OXIDATIVE STRESS FOLLOWING ACUTE EXHAUSTIVE EXERCISE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 4, pp. 845–853, 2013, [Online]. Available: https://sid.ir/paper/288210/en

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