CLARITHROMYCIN DISSOLUTION ENHANCEMENT BY PREPARATION OF AQUEOUS NANOSUSPENSIONS USING SONOPRECIPITATION TECHNIQUE

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ESFANDI ESHAGH; RAMEZANI VAHID; VATANARA ALIREZA; ROUHOLAMINI NAJAFABADI ABDOLHOSSEIN; HADIPOUR MOGHADDAM SEYYED POUYA

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:3 Page(s): 809-818

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Title

CLARITHROMYCIN DISSOLUTION ENHANCEMENT BY PREPARATION OF AQUEOUS NANOSUSPENSIONS USING SONOPRECIPITATION TECHNIQUE

Author(s)

Keywords

CLARITHROMYCIN

NANOSUSPENSION

SOLUBILITY

STABILIZER

ANTIMICROBIAL ACTIVITY

Abstract

CLARITHROMYCIN (CLM) is a member of macrolide family with broad spectrum antibiotic activity. It is practically insoluble in water and its poor SOLUBILITY is pH dependent. In this study, series of NANOSUSPENSIONs containing CLM and STABILIZER such as HPMC, NaCMC, polysorbate 80, poloxamer 188 and polyvinyl alcohol in various ratios were prepared using sonoprecipitation method. Briefly, CLM was dissolved in acid solution and the pH of solution was raised under sonication and the effects of different STABILIZERs on particle size of nanoparticles were evaluated. Characterization of nanoparticles in terms of size, polydispersity index, zeta potential, differential scanning calorimetery and dissolution studies was performed. ANTIMICROBIAL ACTIVITY of CLM NANOSUSPENSION was compared with coarse powder by using an agar well diffusion method. The results showed that HPMC was more efficient in size reduction of particles and presence of HPMC E5 with ratio of 3: 5 to CLM in formulation led to develop the stable NANOSUSPENSION with particle size of 340 nm. The obtained NANOSUSPENSION successfully showed enhanced dissolution rate and ANTIMICROBIAL ACTIVITY.

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APA: Copy

ESFANDI, ESHAGH, RAMEZANI, VAHID, VATANARA, ALIREZA, ROUHOLAMINI NAJAFABADI, ABDOLHOSSEIN, & HADIPOUR MOGHADDAM, SEYYED POUYA. (2014). CLARITHROMYCIN DISSOLUTION ENHANCEMENT BY PREPARATION OF AQUEOUS NANOSUSPENSIONS USING SONOPRECIPITATION TECHNIQUE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(3), 809-818. SID. https://sid.ir/paper/288268/en

Vancouver: Copy

ESFANDI ESHAGH, RAMEZANI VAHID, VATANARA ALIREZA, ROUHOLAMINI NAJAFABADI ABDOLHOSSEIN, HADIPOUR MOGHADDAM SEYYED POUYA. CLARITHROMYCIN DISSOLUTION ENHANCEMENT BY PREPARATION OF AQUEOUS NANOSUSPENSIONS USING SONOPRECIPITATION TECHNIQUE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(3):809-818. Available from: https://sid.ir/paper/288268/en

IEEE: Copy

ESHAGH ESFANDI, VAHID RAMEZANI, ALIREZA VATANARA, ABDOLHOSSEIN ROUHOLAMINI NAJAFABADI, and SEYYED POUYA HADIPOUR MOGHADDAM, “CLARITHROMYCIN DISSOLUTION ENHANCEMENT BY PREPARATION OF AQUEOUS NANOSUSPENSIONS USING SONOPRECIPITATION TECHNIQUE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 3, pp. 809–818, 2014, [Online]. Available: https://sid.ir/paper/288268/en

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