Enhancement of Anti-Dermatitis Potential of Clobetasol Propionate by DHA [Docosahexaenoic Acid] Rich Algal Oil Nanoemulsion Gel

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SARFARAZ ALAM MOHAMMAD; Ali Mohammad Sajid; Zakir Foziyah; ALAM NAWAZISH; Alam Mohammad Intakhab; Ahmad Faruque; RAZA SIDDIQUI MASOOM; Ali Mohammad Daud; Ansari Mohammad Salahuddin; AHMAD SARFARAZ; Ali Maksood

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Journal: Iranian Journal of Pharmaceutical Research Year:2016 | Volume:15 | Issue:1 Page(s): 35-52

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Title

Enhancement of Anti-Dermatitis Potential of Clobetasol Propionate by DHA [Docosahexaenoic Acid] Rich Algal Oil Nanoemulsion Gel

Author(s)

Keywords

Algal Oil

Anti-inflammatory study

Clobetasol Propionate

Contact Dermatitis

Nanoemulsion

Abstract

The aim of the present study was to investigate the potential of Nanoemulsion formulation for topical delivery of Clobetasol Propionate (CP) using Algal Oil (containing omega-3 fatty acids) as the oil phase. CP has anti-inflammatory, immunomodulatory and antiproliferative activities. However, its clinical use is restricted to some extent due to its poor permeability across the skin. Algal Oil was used as the oil phase and was also exploited for its anti-inﬂ ammatory effect along with CP in the treatment of inﬂ ammation associated with dermatitis. Nanoemulsion formulations were prepared by aqueous phase titration method, using Algal Oil, tween 20, PEG 200 and water as the oil phase, surfactant, co-surfactant and aqueous phase respectively. Furthermore, different formulations were subjected to evaluate for ex-vivo permeation and in-vivo anti-inflammatory, irritation and Contact Dermatitis studies. The optimized Nanoemulsion was converted into hydrogel-thickened Nanoemulsion system (HTN) using carbopol 971 and had a viscosity of 97. 57 ± 0. 04 PaS. The optimized formulation had small average diameter (120 nm) with zeta potential of-37. 01 mV which indicated good long-term stability. In-vivo anti-inﬂ ammatory activity indicated 84. 55% and 41. 04% inhibition of inflammation for drug loaded and placebo formulations respectively. The assessment of skin permeation was done by DSC and histopathology studies which indicated changes in the structure of epidermal membrane of skin. Contact Dermatitis reveals that the higher NTPDase activity in the treatment with the CP-loaded Nanoemulsion could be related to the higher anti-inflammatory effect in comparison with placebo Nanoemulsion gel.

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APA: Copy

SARFARAZ ALAM, MOHAMMAD, Ali, Mohammad Sajid, Zakir, Foziyah, ALAM, NAWAZISH, Alam, Mohammad Intakhab, Ahmad, Faruque, RAZA SIDDIQUI, MASOOM, Ali, Mohammad Daud, Ansari, Mohammad Salahuddin, AHMAD, SARFARAZ, & Ali, Maksood. (2016). Enhancement of Anti-Dermatitis Potential of Clobetasol Propionate by DHA [Docosahexaenoic Acid] Rich Algal Oil Nanoemulsion Gel. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(1), 35-52. SID. https://sid.ir/paper/288540/en

Vancouver: Copy

SARFARAZ ALAM MOHAMMAD, Ali Mohammad Sajid, Zakir Foziyah, ALAM NAWAZISH, Alam Mohammad Intakhab, Ahmad Faruque, RAZA SIDDIQUI MASOOM, Ali Mohammad Daud, Ansari Mohammad Salahuddin, AHMAD SARFARAZ, Ali Maksood. Enhancement of Anti-Dermatitis Potential of Clobetasol Propionate by DHA [Docosahexaenoic Acid] Rich Algal Oil Nanoemulsion Gel. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(1):35-52. Available from: https://sid.ir/paper/288540/en

IEEE: Copy

MOHAMMAD SARFARAZ ALAM, Mohammad Sajid Ali, Foziyah Zakir, NAWAZISH ALAM, Mohammad Intakhab Alam, Faruque Ahmad, MASOOM RAZA SIDDIQUI, Mohammad Daud Ali, Mohammad Salahuddin Ansari, SARFARAZ AHMAD, and Maksood Ali, “Enhancement of Anti-Dermatitis Potential of Clobetasol Propionate by DHA [Docosahexaenoic Acid] Rich Algal Oil Nanoemulsion Gel,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 1, pp. 35–52, 2016, [Online]. Available: https://sid.ir/paper/288540/en

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