ANTI-OXIDANT AND ANTI-INFLAMMATORY CYCLIC DIARYLHEPTANOIDS FROM ALNUS JAPONICA STEM BARK

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IBRAHIM SABRIN R.M.; MOHAMED GAMAL A.; KHEDR AMGAD I.M.; ALJAEID BADER M.

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:SUPPLEMENT Page(s): 83-91

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Information Journal Paper

Title

ANTI-OXIDANT AND ANTI-INFLAMMATORY CYCLIC DIARYLHEPTANOIDS FROM ALNUS JAPONICA STEM BARK

Author(s)

IBRAHIM SABRIN R.M. | MOHAMED GAMAL A. | KHEDR AMGAD I.M. | ALJAEID BADER M. | Issue Writer Certificate

Keywords

ALNUS JAPONICA

ALNUHEPTANOID B

CYCLIC DIARYLHEPTANOID

ANTIOXIDANT

ANTIINFLAMMATORY

Abstract

A new CYCLIC DIARYLHEPTANOID namely ALNUHEPTANOID B (3), along with four known CYCLIC DIARYLHEPTANOIDs: myricanone (1), (+) - S -myricanol (2), myricanone 5- O- b-D-glucopyranoside (4), and (+) - S -myricanol 5- O- b-D-glucopyranoside (5) were isolated from the EtOAc fraction of ALNUS JAPONICA Steud (family: Betulaceae) stem bark. Their structures were established by different spectroscopic analyses, as well as optical rotation measurement. Compounds 1, 2, 4, and 5 are isolated for the first time from A. japonica. The ANTIOXIDANT and anti-inflammatory activities of compounds (1-5) were assessed using DPPH assay and carrageenin induced rat paw edema model, respectively. They displayed significant ANTIOXIDANT activity in relation to propyl gallate (standard ANTIOXIDANT) at concentration 50 mM. Compound 2 demonstrated anti-inflammatory effect at a dose 10 mg/kg compared with indomethacin (positive control).

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APA: Copy

IBRAHIM, SABRIN R.M., MOHAMED, GAMAL A., KHEDR, AMGAD I.M., & ALJAEID, BADER M.. (2017). ANTI-OXIDANT AND ANTI-INFLAMMATORY CYCLIC DIARYLHEPTANOIDS FROM ALNUS JAPONICA STEM BARK. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(SUPPLEMENT), 83-91. SID. https://sid.ir/paper/288578/en

Vancouver: Copy

IBRAHIM SABRIN R.M., MOHAMED GAMAL A., KHEDR AMGAD I.M., ALJAEID BADER M.. ANTI-OXIDANT AND ANTI-INFLAMMATORY CYCLIC DIARYLHEPTANOIDS FROM ALNUS JAPONICA STEM BARK. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(SUPPLEMENT):83-91. Available from: https://sid.ir/paper/288578/en

IEEE: Copy

SABRIN R.M. IBRAHIM, GAMAL A. MOHAMED, AMGAD I.M. KHEDR, and BADER M. ALJAEID, “ANTI-OXIDANT AND ANTI-INFLAMMATORY CYCLIC DIARYLHEPTANOIDS FROM ALNUS JAPONICA STEM BARK,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. SUPPLEMENT, pp. 83–91, 2017, [Online]. Available: https://sid.ir/paper/288578/en

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